Correlation between preoperative serum alpha-fetoprotein levels and survival with respect to the surgical treatment of hepatocellular carcinoma at a tertiary care hospital in Veracruz, Mexico.

Autor:	Martínez-Mier G; Departamento de Trasplantes de Órganos, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México. Electronic address: gmtzmier@gmail.com., Esquivel-Torres S; Departamento de Cirugía Oncológica, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México., Nava-Lacorte A; Departamento de Cirugía Oncológica, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México., Lajud-Barquín FA; Departamento de Investigación, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México., Zilli-Hernández S; Departamento de Investigación, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México., Vázquez-Ramírez LM; Departamento de Investigación, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México.
Jazyk:	English; Spanish; Castilian
Zdroj:	Revista de gastroenterologia de Mexico [Rev Gastroenterol Mex] 2017 Oct - Dec; Vol. 82 (4), pp. 357-360.
DOI:	10.1016/j.rgmx.2017.03.009
Abstrakt:	Introduction: Preoperative serum alpha-fetoprotein levels can have predictive value for hepatocellular carcinoma survival. Aim: Our aim was to analyze the correlation between preoperative serum alpha-fetoprotein levels and survival, following the surgical treatment of hepatocellular carcinoma. Methods: Nineteen patients were prospectively followed (07/2005-01/2016). An ROC curve was created to determine the sensitivity and specificity of alpha-fetoprotein in relation to survival (Kaplan-Meier). Results: Of the 19 patients evaluated, 57.9% were men. The mean patient age was 68.1 ± 8.5 years and survival at 1, 3, and 5 years was 89.4, 55.9, and 55.9%. The alpha-fetoprotein cutoff point was 15.1 ng/ml (sensitivity 100%, specificity 99.23%). Preoperative alpha-fetoprotein levels below 15.1, 200, 400, and 463 ng/ml correlated with better 1 and 5-year survival rates than levels above 15.1, 200, 400, and 463 ng/ml (P<.05). Conclusions: Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival. (Copyright © 2017 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.)
Databáze:	MEDLINE
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