Comparative efficacy evaluation of catheter intraperitoneal chemotherapy, normothermic and hyperthermic chemoperfusion in a rat model of ascitic ovarian cancer.

Autor: Bespalov VG; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Alvovsky IK; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Tochilnikov GV; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Stukov AN; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Vyshinskaya EA; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Semenov AL; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Vasilyeva IN; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Belyaeva OA; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Kireeva GS; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Senchik KY; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Zhilinskaya NT; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Von JD; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Krasilnikova LA; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia., Alexandrov VA; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Khromov-Borisov NN; c Scientific Council, R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics , St. Petersburg , Russia., Baranenko DA; b International Research Centre 'Biotechnologies of the Third Millennium', ITMO University , St. Petersburg , Russia., Belyaev AM; a Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology , N.N. Petrov Research Institute of Oncology , St. Petersburg , Russia.
Jazyk: angličtina
Zdroj: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2018 Aug; Vol. 34 (5), pp. 545-550. Date of Electronic Publication: 2017 Sep 18.
DOI: 10.1080/02656736.2017.1375161
Abstrakt: Objectives: The choice of an optimal administration route for intraperitoneal (IP) chemotherapy and a suitable chemotherapeutic regime in the treatment of ovarian cancer remains a controversy. We investigated survival outcomes according to catheter intraperitoneal chemotherapy (CIPC), normothermic and hyperthermic chemoperfusion (NIPEC and HIPEC) with cytostatic drugs dioxadet and cisplatin in rats with transplantable ascitic ovarian cancer.
Methods: Ascitic liquid containing 1 × 10 7 tumour cells was inoculated to female Wistar rats and 48 hours after rats received dioxadet and cisplatin at the maximum tolerated doses. Dioxadet at doses 1.5, 30 and 15 mg/kg and cisplatin at doses 4, 40 and 20 mg/kg body weight were administered for CIPC, NIPEC and HIPEC, respectively. Rats in the control groups received physiological saline and CIPC with physiological saline was regarded as the untreated control. The antitumor activity of the drugs was evaluated as an increase in average life expectancy (ALE). Analysis of the data was based primarily on Bayesian statistics and included Kaplan-Meier method, log-rank test and hazard ratio (HR) estimation.
Results: Compared to the untreated control CIPC, NIPEC and HIPEC with dioxadet significantly increased ALE by 10 13 16 , 6 15 24 and 1.7 17 35  days, whereas with cisplatin by 6 10 13 , 12 24 37 and -13 5 23  days, respectively.
Conclusions: Dioxadet and cisplatin show similar efficacy in the CIPC route. Compared with CIPC IP chemotherapy by chemoperfusions is more effective for both the drugs. Dioxadet in HIPEC showed highest survival benefit whereas largest effect during NIPEC is achieved with cisplatin.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje