Nanoscale mapping of refractive index by using scattering-type scanning near-field optical microscopy.

Autor: Tranca DE; Center for Microscopy-Microanalysis and Information Processing, University Politehnica of Bucharest, Bucharest, Romania., Stanciu SG; Center for Microscopy-Microanalysis and Information Processing, University Politehnica of Bucharest, Bucharest, Romania., Hristu R; Center for Microscopy-Microanalysis and Information Processing, University Politehnica of Bucharest, Bucharest, Romania., Witgen BM; Development Bioanalysis, Global Research, Novo Nordisk A/S, Måløv, Denmark., Stanciu GA; Center for Microscopy-Microanalysis and Information Processing, University Politehnica of Bucharest, Bucharest, Romania. Electronic address: stanciu@physics.pub.ro.
Jazyk: angličtina
Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2018 Jan; Vol. 14 (1), pp. 47-50. Date of Electronic Publication: 2017 Sep 05.
DOI: 10.1016/j.nano.2017.08.016
Abstrakt: We present a novel method for nanoscale reconstruction of complex refractive index by using scattering-type Scanning Near-field Optical Microscopy (s-SNOM). Our method relies on correlating s-SNOM experimental image data with computational data obtained through simulation of the classical oscillating point-dipole model. This results in assigning a certain dielectric function for every pixel of the s-SNOM images, which further results in nanoscale mapping of the refractive index. This method is employed on human erythrocytes to demonstrate the approach in a biologically relevant manner. The presented results advance the current knowledge on the capabilities of s-SNOM to extract quantitative information with nanoscale resolution from optical data sets with biological application.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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