| Autor: |
Ghoreishizadeh SS, Taurino I, De Micheli G, Carrara S, Georgiou P |
| Jazyk: |
angličtina |
| Zdroj: |
IEEE transactions on biomedical circuits and systems [IEEE Trans Biomed Circuits Syst] 2017 Oct; Vol. 11 (5), pp. 1148-1159. Date of Electronic Publication: 2017 Sep 05. |
| DOI: |
10.1109/TBCAS.2017.2733624 |
| Abstrakt: |
A monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing in CMOS. The system consists of a fully integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing platinum nanostructures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudodifferential integrators for concurrent sampling of the differential sensor currents. The circuit further includes a differential to single converter and a programmable gain amplifier prior to an ADC. The system is fabricated in [Formula: see text] technology and measures current within [Formula: see text] with minimum input-referred noise of [Formula: see text] and consumes [Formula: see text] from a [Formula: see text] supply. Differential sensing for nanostructured sensors is proposed to build highly sensitive and offset-free sensors for metabolite detection. This is successfully tested for bio-nano-sensors for the measurement of glucose in submilli molar concentrations with the proposed readout IC. The on-die electrodes are nanostructured and cyclic voltammetry run successfully through the readout IC to demonstrate detection of [Formula: see text]. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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