Five gene variants in nonagenarians, centenarians and average individuals.

Autor: Kolovou V; Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece., Bilianou H; Cardiology Department, Tzanio Hospital, Pireus, Greece., Giannakopoulou V; Cardiology Department, Tzanio Hospital, Pireus, Greece., Kalogeropoulos P; Department of Cardiology, Kostantopoulio Geniko Nosokomio Neas Ionias, Athens, Greece., Mihas C; Internal Medicine Department, Kimi General Hospital, Kimi, Greece., Kouris M; Cardiology Department, Tzanio Hospital, Pireus, Greece., Cokkinos DV; Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece., Boutsikou M; Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece., Hoursalas I; Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece., Mavrogeni S; Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece., Katsiki N; Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece., Kolovou G; Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Jazyk: angličtina
Zdroj: Archives of medical science : AMS [Arch Med Sci] 2017 Aug; Vol. 13 (5), pp. 1130-1141. Date of Electronic Publication: 2017 Aug 03.
DOI: 10.5114/aoms.2017.68942
Abstrakt: Introduction: Genetic factors contribute to the variation of human life span which is believed to be more profound after 85 years of age. The aim of the present study was to evaluate the frequency of 5 gene polymorphisms between nonagenarians, centenarians and average individuals.
Material and Methods: Single nucleotide polymorphisms (SNPs) of telomerase reverse transcriptase ( TERT ; rs2736098), insulin-like growth factor-1 binding protein-3 ( IGFBP3 ; A-202C, rs2857744), fork-head box O3A ( FOXO3A ; rs13217795 and rs2764264) factor and adiponectin ( ADIPOQ ; rs2241766) were evaluated in 405 individuals: n = 256 nonagenarians and centenarians (study group) and n = 149 average lifespan individuals (control group aged 18 - < 80 years).
Results: The frequency of women was significantly higher in the study group than the control group (64.5 vs. 49.7%, p = 0.004). Genotypic and allele frequencies did not differ between groups according to gender. However, in men, the frequency of TT genotype of FOXO3A ; rs2764264 was higher in the study group than the control group (45.6 vs. 28.0%, p = 0.05). Overall, the frequency of the C allele of FOXO3A ; rs2764264 was significantly lower in the study group than the control group (3.9 vs. 9.5%, respectively, p = 0.023). Furthermore, in the study group, the T allele was significantly more frequent in the nonagenarians ( n = 239) than the centenarians ( n = 17) in both FOXO3A ; rs13217795 and rs2764264 (64.4 vs. 44.1%, p = 0.018 and 69.7 vs. 50.0%, p = 0.017, respectively).
Conclusions: According to survival status, there is differentiation in the prevalence of both studied FOXO3A gene polymorphisms. The study group had half of the C alleles compared with the control group and centenarians less frequently had the T allele of both FOXO3A gene polymorphisms compared with nonagenarians. No difference was found between groups according to TERT , IGFBP3 and ADIPOQ gene polymorphisms. It seems that some polymorphisms may be significant in prolonging our lifespan. Nevertheless, confirmation in additional study populations is needed.
Databáze: MEDLINE
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