Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities.

Autor: Osei-Safo D; Chemistry Department, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P. O. Box LG 56, Legon, Accra, Ghana. Electronic address: dosei-safo@ug.edu.gh., Dziwornu GA; Chemistry Department, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P. O. Box LG 56, Legon, Accra, Ghana; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa. Electronic address: dzwgod001@myuct.ac.za., Salgado A; Centro de Espectroscopía de RMN (CERMN), CAI Químicas, University of Alcalá, E-28805, Alcalá de Henares, Madrid, Spain. Electronic address: a.salgado@uah.es., Sunassee SN; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa. Electronic address: sunny.sunassee@uct.ac.za., Chama MA; Chemistry Department, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P. O. Box LG 56, Legon, Accra, Ghana.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2017 Oct; Vol. 122, pp. 95-100. Date of Electronic Publication: 2017 Sep 04.
DOI: 10.1016/j.fitote.2017.09.001
Abstrakt: Two new bisbibenzyls, heudelotol A (1) and B (2), along with the known bibenzyls, (E)-combretastatin A-1 (3) and combretastatin B-1 (4) have been isolated from the ethyl acetate extract of the roots of Dichapetalum heudelotii. Structure elucidation of all four isolated compounds was achieved using UV, IR, 1D and 2D NMR spectroscopy and HR-Mass Spectrometry. The compounds exhibited varying antiproliferative activity against six cancer cell lines using the CellTiter-Glo® Luminiscent Cell Viability Assay. Compound 3 was found to be the most active with sub-micromolar growth inhibition concentrations against all the cell lines (GI 50 0.03-0.72μM). However, it was about ten-fold less active than the positive control, taxol. The new bisbibenzyls heudelotol A and B exhibited good activity against human pancreatic adenocarcinoma (GI 50 9.04μM) and Burkitt's lymphoma (GI 50 4.67μM) respectively, and average activity against the other cancer cell lines.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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