Taurine restores the exploratory behavior following alcohol withdrawal and decreases BDNF mRNA expression in the frontal cortex of chronic alcohol-treated rats.

Autor: Hansen AW; Programa de Pós Graduação em Ciências Biológicas, Farmacologia e Terapêutica, Laboratório de Álcool e Tabaco (LAT), Universidade Federal do Rio Grande do Sul - UFRGS, Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil. Electronic address: alana.hansen@ufrgs.br., Almeida FB; Programa de Pós Graduação de Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Sarmento Leite, 245, 90050-170 Porto Alegre, RS, Brazil., Bandiera S; Programa de Pós Graduação em Ciências Biológicas, Farmacologia e Terapêutica, Laboratório de Álcool e Tabaco (LAT), Universidade Federal do Rio Grande do Sul - UFRGS, Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil., Pulcinelli RR; Programa de Pós Graduação em Ciências Biológicas, Farmacologia e Terapêutica, Laboratório de Álcool e Tabaco (LAT), Universidade Federal do Rio Grande do Sul - UFRGS, Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil., Fragoso ALR; Programa de Pós Graduação em Ciências Biológicas, Farmacologia e Terapêutica, Laboratório de Álcool e Tabaco (LAT), Universidade Federal do Rio Grande do Sul - UFRGS, Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil., Schneider R Jr; Programa de Pós Graduação em Ciências Biológicas, Farmacologia e Terapêutica, Laboratório de Álcool e Tabaco (LAT), Universidade Federal do Rio Grande do Sul - UFRGS, Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil., Barros HMT; Programa de Pós Graduação de Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Sarmento Leite, 245, 90050-170 Porto Alegre, RS, Brazil., Gomez R; Programa de Pós Graduação em Ciências Biológicas, Farmacologia e Terapêutica, Laboratório de Álcool e Tabaco (LAT), Universidade Federal do Rio Grande do Sul - UFRGS, Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil; Programa de Pós Graduação de Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Sarmento Leite, 245, 90050-170 Porto Alegre, RS, Brazil.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2017 Oct; Vol. 161, pp. 6-12. Date of Electronic Publication: 2017 Sep 05.
DOI: 10.1016/j.pbb.2017.09.001
Abstrakt: Alcohol use disorder is an alarming health problem, and the withdrawal symptoms increase the risk of relapse. We have hypothesized that taurine, a multitarget substance acting as a gamma-aminobutyric acid A receptor (GABA A R) positive modulator and a partial inhibitor of N-methyl-d-aspartate (NMDA) glutamate receptors, may reduce the withdrawal symptoms or modify behaviors when combined with alcohol. Therefore, we investigated the effects of taurine on behavior in the open field test (OFT), the GABA A R α 2 subunit and BDNF mRNA expression in the frontal cortex of rats after chronic alcohol treatment or upon withdrawal. Rats received alcohol 2g/kg (alcohol and withdrawal groups) or water (control group) twice daily by oral gavage for 28days. On day 29, the withdrawal rats received water instead of alcohol, and all groups were reallocated to receive 100mg/kg taurine or vehicle intraperitoneally, once a day for 5days. On day 33, the rats were exposed to OFT; 18h later, they were euthanized, and the frontal cortex was dissected for GABA A R α 2 subunit detection and BDNF mRNA expression determination by real-time quantitative PCR. Taurine administration restored rearing behavior to the control levels in the withdrawal rats. Taurine also showed anxiolytic-like effects in control rats and did not change the behaviors in the chronic alcohol group. Chronic alcohol treatment or withdrawal did not change the GABA A R α 2 subunit or BDNF mRNA expression in the frontal cortex, but taurine decreased the α 2 subunit level in control rats and to the BDNF levels in the alcohol rat group. We conclude that taurine restored exploratory behavior after alcohol withdrawal but that this effect was not related to the GABA A R α 2 subunit or BDNF mRNA expression in the frontal cortex of the rats.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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