Polio immunity and the impact of mass immunization campaigns in the Democratic Republic of the Congo.

Autor: Voorman A; The Bill and Melinda Gates Foundation, Seattle 98109, USA., Hoff NA; Department of Epidemiology, University of California, Los Angeles 90095, USA., Doshi RH; Department of Epidemiology, University of California, Los Angeles 90095, USA., Alfonso V; Department of Epidemiology, University of California, Los Angeles 90095, USA., Mukadi P; National Institute for Biomedical Research (INRB), Kinshasa, The Democratic Republic of the Congo., Muyembe-Tamfum JJ; National Institute for Biomedical Research (INRB), Kinshasa, The Democratic Republic of the Congo., Wemakoy EO; Kinshasa School of Public Health, Kinshasa, The Democratic Republic of the Congo., Bwaka A; Expanded Programme on Immunization, McKing Consulting, Kinshasa, The Democratic Republic of the Congo., Weldon W; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta 30329, USA., Gerber S; The Bill and Melinda Gates Foundation, Seattle 98109, USA., Rimoin AW; Department of Epidemiology, University of California, Los Angeles 90095, USA. Electronic address: arimoin@ucla.edu.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2017 Oct 09; Vol. 35 (42), pp. 5693-5699. Date of Electronic Publication: 2017 Sep 04.
DOI: 10.1016/j.vaccine.2017.08.063
Abstrakt: Background: In order to prevent outbreaks from wild and vaccine-derived poliovirus, maintenance of population immunity in non-endemic countries is critical.
Methods: We estimated population seroprevalence using dried blood spots collected from 4893 children 6-59months olds in the 2013-2014 Demographic and Health Survey in the Democratic Republic of the Congo (DRC).
Results: Population immunity was 81%, 90%, and 70% for poliovirus types 1, 2, and 3, respectively. Among 6-59-month-old children, 78% reported at least one dose of polio in routine immunization, while only 15% had three doses documented on vaccination cards. All children in the study had been eligible for at least two trivalent oral polio vaccine campaigns at the time of enrollment; additional immunization campaigns seroconverted 5.0%, 14%, and 5.5% of non-immune children per-campaign for types 1, 2, and 3, respectively, averaged over relevant campaigns for each serotype.
Conclusions: Overall polio immunity was high at the time of the study, though pockets of low immunity cannot be ruled out. The DRC still relies on supplementary immunization campaigns, and this report stresses the importance of the quality and coverage of those campaigns over their quantity, as well as the importance of routine immunization.
(Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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