Association of the leptin-to-adiponectin ratio with metabolic syndrome in a sub-Saharan African population.

Autor: Ayina CNA; Department of Animal Science, Faculty of Science, University of Douala, Douala, Cameroon., Endomba FTA; Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Science, University of Yaoundé I, Yaoundé, Cameroon., Mandengue SH; Department of Animal Science, Faculty of Science, University of Douala, Douala, Cameroon., Noubiap JJN; Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa., Ngoa LSE; Department of Animal Science, Higher Teacher's Training College, University of Yaoundé I, Yaounde, Cameroon., Boudou P; Department of Hormonal Biology, Saint-Louis Hospital, Public Assistance -Paris Hospitals, University Paris-Diderot Paris-7, Paris, France., Gautier JF; Department of Diabetes and Endocrinology, Lariboisiere Hospital, Public Assistance - Paris Hospitals, University Paris-Diderot Paris-7, Paris, France.; INSERM UMRS 1138, Cordeliers Research Centre, University Pierre et Marie Curie-Paris 6, Paris, France., Mbanya JC; Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Science, University of Yaoundé I, Yaoundé, Cameroon.; Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon.; National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon., Sobngwi E; Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Science, University of Yaoundé I, Yaoundé, Cameroon.; Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon.; National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.
Jazyk: angličtina
Zdroj: Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2017 Sep 05; Vol. 9, pp. 66. Date of Electronic Publication: 2017 Sep 05 (Print Publication: 2017).
DOI: 10.1186/s13098-017-0265-6
Abstrakt: Background: Worldwide there is an increased prevalence of metabolic syndrome mainly due to life-style modifications, and Africans are not saved of this situation. Many markers have been studied to predict the risk of this syndrome but the most used are leptin and adiponectin. Data on these metabolic markers are scare in Africa and this study aimed to assess the association between the leptin-to-adiponectin ratio (LAR) with metabolic syndrome in a Cameroonian population.
Methods: This was a cross-sectional study that included 476 adults among a general population of Cameroon. Data collected concerned the body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, plasma lipids, adiponectin, leptin, insulin and homeostasis model for assessment of insulin resistance (HOMA-IR). To assess correlations we used Spearman's analyses and association of the studied variables with metabolic syndrome were done using binary logistic regression analysis.
Results: The leptin to adiponectin ratio was significantly and positively correlated with the body mass index (r = 0.669, p < 0.0001), waist circumference (r = 0.595, p < 0.0001), triglycerides (r = 0.190, p = 0.001), insulin levels (r = 0.333, p < 0.0001) and HOMA-IR (r = 0.306, p < 0.0001). Binary logistic regression analysis revealed that leptin, adiponectin and LAR were significantly associated with metabolic syndrome with respective unadjusted OR of 1.429, 0.468 and 1.502. After adjustment, for age and sex, the associations remained significative; LAR was also found to be significantly associated with metabolic syndrome (OR = 1.573, p value =0.000) as well as lower levels of adiponectin (OR = 0.359, p value =0.000) and higher levels of leptin (OR = 1.469, p value =0.001).
Conclusion: This study revealed that LAR is significantly associated with metabolic syndrome in sub-Saharan African population, independently to age and sex.
Databáze: MEDLINE
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