Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization.
| Autor: | Maamary J; Leonard Wagner Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065., Wang TT; Leonard Wagner Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065.; Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305.; Chan Zuckerberg Biohub, San Francisco, CA 94158., Tan GS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Ravetch JV; Leonard Wagner Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065; ravetch@rockefeller.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Sep 19; Vol. 114 (38), pp. 10172-10177. Date of Electronic Publication: 2017 Sep 05. |
| DOI: | 10.1073/pnas.1707950114 |
| Abstrakt: | The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine that elicits broad protection against different virus strains. Studies in preclinical models of influenza virus infections have shown that antibodies alone are sufficient to provide broad protection against divergent virus strains in vivo. Here, we address the challenge of identifying an immunogen that can elicit potent, broadly protective, antiinfluenza antibodies by demonstrating that immune complexes composed of sialylated antihemagglutinin antibodies and seasonal inactivated flu vaccine (TIV) can elicit broadly protective antihemagglutinin antibodies. Further, we found that an Fc-modified, bispecific monoclonal antibody against conserved epitopes of the hemagglutinin can be combined with TIV to elicit broad protection, thus setting the stage for a universal influenza virus vaccine. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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