Candida bloodstream infections in Serbia: First multicentre report of a national prospective observational survey in intensive care units.

Autor: Arsić Arsenijević V; Faculty of Medicine, Institute of Microbiology and Immunology, National Medical Mycology Reference Laboratory, University of Belgrade, Belgrade, Serbia., Otašević S; Department of Microbiology & Public Health Institute Clinical Center of Nis, Faculty of Medicine, University of Niš, Niš, Serbia., Janić D; Department of Hematology/Oncology, Faculty of Medicine, University Children's Hospital, University of Belgrade, Belgrade, Serbia., Minić P; Department of Pulmonology Mother and Child Health Institute of Serbia, Faculty of Medicine, University of Belgrade, Beograd, Serbia., Matijašević J; Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, University of Novi Sad, Novi Sad, Serbia., Medić D; Faculty of Medicine, Institute of Public Health of Vojvodina, University of Novi Sad, Novi Sad, Serbia., Savić I; Department of Hematology, Faculty of Medicine, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia., Delić S; Center for Microbiology, Public Health Institute Sombor, Sombor, Serbia., Nestorović Laban S; Department of Clinical Microbiology, Mother and Child Health Care Institute of Serbia, Belgrade, Serbia., Vasiljević Z; Department of Microbiology, Univerity Children's Hospital, Belgrade, Serbia., Hadnadjev M; Center for Microbiology, Virology and Immunology, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
Jazyk: angličtina
Zdroj: Mycoses [Mycoses] 2018 Feb; Vol. 61 (2), pp. 70-78. Date of Electronic Publication: 2017 Sep 28.
DOI: 10.1111/myc.12700
Abstrakt: Candida bloodstream infections (BSI) are a significant cause of mortality in intensive care units (ICU), hereof the prospective 12-months (2014-2015) hospital- and laboratory-based survey was performed at the Serbian National Reference Medical Mycology Laboratory (NRMML). Candida identification was done by a matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and a susceptibility test, according to the Clinical and Laboratory Standards Institute methodology. Among nine centres (265 beds; 10 820 patient admissions), four neonatal/paediatric (NICU/PICUs) and five adult centres (ICUs) participated, representing 89 beds and 3446 patient admissions, 166 beds and 7347 patient admissions respectively. The NRMML received 43 isolates, 17 from NICU/PICUs and 26 from adult ICUs. C. albicans dominated highly in NICU/PICUs (~71%), whereas C. albicans and C. parapsilosis were equally distributed within adults (46%, each), both accounting for ~90% of received isolates. The resistance to itraconazole and flucytosine were 25% and 2.4% respectively. In addition, the 2 C. albicans were azole cross-resistant (4.6%). The overall incidence of CandidaBSI was ~3.97 cases/1000 patient admissions (4.93 in NICU/PICU and 3.53 in adult ICU). The 30-day mortality was ~37%, most associated with C. tropicalis and C. glabrataBSI. Data from this national survey may contribute to improving the Balkan and Mediterranean region epidemiology of CandidaBSI within ICUs.
(© 2017 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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