Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new "B2" configuration of the RA-6 nuclear reactor.

Autor: Monti Hughes A; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina. montihug@cnea.gov.ar.; National Research Council (CONICET), Ciudad Autonoma de Buenos Aires, Argentina. montihug@cnea.gov.ar., Longhino J; Department of Nuclear Engineering, Bariloche Atomic Center, CNEA, San Carlos de Bariloche, Province Rio Negro, Argentina., Boggio E; Department of Nuclear Engineering, Bariloche Atomic Center, CNEA, San Carlos de Bariloche, Province Rio Negro, Argentina., Medina VA; National Research Council (CONICET), Ciudad Autonoma de Buenos Aires, Argentina.; Laboratory of Tumoral Biology and Inflammation, School of Medical Sciences, Institute for Biomedical Research (BIOMED CONICET-UCA), Pontifical Catholic University of Argentina (UCA), Ciudad Autonoma de Buenos Aires, Argentina., Martinel Lamas DJ; National Research Council (CONICET), Ciudad Autonoma de Buenos Aires, Argentina.; Laboratory of Tumoral Biology and Inflammation, School of Medical Sciences, Institute for Biomedical Research (BIOMED CONICET-UCA), Pontifical Catholic University of Argentina (UCA), Ciudad Autonoma de Buenos Aires, Argentina., Garabalino MA; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina., Heber EM; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina., Pozzi ECC; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina., Itoiz ME; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina.; Department of Oral Pathology, Faculty of Dentistry, UBA, Ciudad Autonoma de Buenos Aires, Argentina., Aromando RF; Department of Oral Pathology, Faculty of Dentistry, UBA, Ciudad Autonoma de Buenos Aires, Argentina., Nigg DW; Idaho National Laboratory, Idaho Falls, USA., Trivillin VA; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina.; National Research Council (CONICET), Ciudad Autonoma de Buenos Aires, Argentina., Schwint AE; Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martín, Province Buenos Aires, Argentina.; National Research Council (CONICET), Ciudad Autonoma de Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Radiation and environmental biophysics [Radiat Environ Biophys] 2017 Nov; Vol. 56 (4), pp. 377-387. Date of Electronic Publication: 2017 Sep 04.
DOI: 10.1007/s00411-017-0710-9
Abstrakt: Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the therapeutic effect of BNCT mediated by BPA (boronophenylalanine) in the hamster cheek pouch model of oral cancer, at the RA-6 nuclear reactor. Between 2007 and 2011, the RA-6 was upgraded, leading to an improvement in the performance of the BNCT beam (B2 configuration). Our aim was to evaluate BPA-BNCT radiotoxicity and tumor control in the hamster cheek pouch model of oral cancer at the new "B2" configuration. We also evaluated, for the first time in the oral cancer model, the radioprotective effect of histamine against mucositis in precancerous tissue as the dose-limiting tissue. Cancerized pouches were exposed to: BPA-BNCT; BPA-BNCT + histamine; BO: Beam only; BO + histamine; CONTROL: cancerized, no-treatment. BNCT induced severe mucositis, with an incidence that was slightly higher than in "B1" experiments (86 vs 67%, respectively). BO induced low/moderate mucositis. Histamine slightly reduced the incidence of severe mucositis induced by BPA-BNCT (75 vs 86%) and prevented mucositis altogether in BO animals. Tumor overall response was significantly higher in BNCT (94-96%) than in control (16%) and BO groups (9-38%), and did not differ significantly from the "B1" results (91%). Histamine did not compromise BNCT therapeutic efficacy. BNCT radiotoxicity and therapeutic effect at the B1 and B2 configurations of RA-6 were consistent. Histamine slightly reduced mucositis in precancerous tissue even in this overly aggressive oral cancer model, without compromising tumor control.
Databáze: MEDLINE
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