Critical Overview of HER2 Assessement in Bladder Cancer: What Is Missing for a Better Therapeutic Approach?

Autor:	Cimpean AM; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timisoara, Romania ancacimpean1972@yahoo.com., Tarlui V; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timisoara, Romania., Cumpănaş AA; Department of Ortophedic Surgery, Traumatology and Urology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timisoara, Romania., Bolintineanu S; Department of Anatomy, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timisoara, Romania., Cumpănaş A; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timisoara, Romania., Raica M; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2017 Sep; Vol. 37 (9), pp. 4935-4942.
DOI:	10.21873/anticanres.11903
Abstrakt:	Background/aim: To assess the concordance between IHC and FISH and its influence on tumor type, grade and lympho-vascular invasion (LVI). Materials and Methods: HER2 immunohistochemistry (IHC) to 45 cases of bladder carcinoma, followed by fluorescent in situ hybridization (FISH) were applied. Results: 31.12% cases were IHC positive. Less than 35% of HER2-negative cases presented LVI and this percent increased to 54.54% for +1 HER2 cases. LVI increases up to 57.14% for +2 HER2 cases and slightly decreased for +3 HER2 cases to 42.85%. IHC/FISH concordance was found for 73.34% cases but 31.57% were previously negative and 36.36% scored as +1 by IHC had gene amplification as shown by FISH analysis. T3 was correlated with HER2-IHC (p=0.05) and HER2-FISH (p=0.01). Conclusion: Improved HER2 assessement is needed for urothelial carcinomas. HER2-IHC scored as 0-2 should be validated by and reclassified according to FISH analysis. (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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