Sponge like microparticles for drug delivery and cosmeto-textile use: Formulation and human skin penetration.

Autor: Zafar N; Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622 Lyon, France., Robin S; Laboratory of Engineering and Cutaneous Biology, UMR 1098, Medicine and Pharmaceutical University, 19 rue Ambroise Paré, 25000, Besançon, France., Viennet C; Laboratory of Engineering and Cutaneous Biology, UMR 1098, Medicine and Pharmaceutical University, 19 rue Ambroise Paré, 25000, Besançon, France., Humbert P; Laboratory of Engineering and Cutaneous Biology, UMR 1098, Medicine and Pharmaceutical University, 19 rue Ambroise Paré, 25000, Besançon, France., Valour JP; Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622 Lyon, France., Agusti G; Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622 Lyon, France., Fessi H; Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622 Lyon, France., Elaissari A; Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622 Lyon, France. Electronic address: elaissari@lagep.univ-lyon1.fr.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2017 Oct 30; Vol. 532 (1), pp. 623-634. Date of Electronic Publication: 2017 Sep 01.
DOI: 10.1016/j.ijpharm.2017.08.122
Abstrakt: This unique work is targeted to achieve three main goals: i) to enhance the aqueous solubility of three specifically selected hydrophobic active agents, ii) to prepare such polymeric biodegradable microparticles which can encapsulate actives-cyclodextrin complexes and iii) to functionalize a polyamide base textile with active loaded microparticles and active-cyclodextrin loaded microparticles. To achieve this objective, biodegradable cationic microparticles were prepared via double emulsion solvent evaporation process and were loaded with hydroxypropyl-beta-cyclodextrin based complexes of Indomethacin, α-tocopheroland Lauryl Isoquinolinium Bromide during the formulation process. Inclusion complex based particles were evaluated for their morphology, size distribution, zeta potential, skin penetration aptitude and adsorption onto a selected textile. It was observed that active-cyclodextrin complex encapsulation do not affect the morphology, size and zeta potential of the microparticles as well as adsorption of the microparticles onto textile remains unaltered. However such active-cyclodextrin complex encapsulated particles provided the enhancement in the aqueous solubility of hydrophobic agents and also provided prolonged release formulations.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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