Inconsistency in the reporting of antitubercular drug susceptibility tests in an endemic region.

Autor: Saha A; Department of Respiratory Medicine, Fortis Hiranandani Hospital, Navi Mumbai; Institute of Pulmonology Medical Research and Development, Mumbai, Maharashtra, India., Vaidya PJ; Department of Respiratory Medicine, Fortis Hiranandani Hospital, Navi Mumbai; Institute of Pulmonology Medical Research and Development, Mumbai, Maharashtra, India., Chavhan VB; Department of Respiratory Medicine, Fortis Hiranandani Hospital, Navi Mumbai; Institute of Pulmonology Medical Research and Development, Mumbai, Maharashtra, India., Pandey KV; Department of Respiratory Medicine, Fortis Hiranandani Hospital, Navi Mumbai; Institute of Pulmonology Medical Research and Development, Mumbai, Maharashtra, India., Kate AH; Institute of Pulmonology Medical Research and Development, Mumbai, Maharashtra, India., Chhajed PN; Department of Respiratory Medicine, Fortis Hiranandani Hospital, Navi Mumbai; Institute of Pulmonology Medical Research and Development, Mumbai, Maharashtra, India.
Jazyk: angličtina
Zdroj: Lung India : official organ of Indian Chest Society [Lung India] 2017 Sep-Oct; Vol. 34 (5), pp. 427-429.
DOI: 10.4103/0970-2113.213840
Abstrakt: Background: Individualized treatment for multidrug-resistant tuberculosis (MDR TB) is associated with improved outcomes. Therapy needs to be tailored to drug susceptibility testing (DST) results. We present our observations on the inconsistency in DST reporting in an endemic region with a high prevalence of MDR TB.
Methods: We retrospectively analyzed 118 DST reports from 10 different laboratories.
Observations: Of 118 patients, only 79 (67%) had DST reports with results to all first-line drugs, a fluoroquinolone (excluding ciprofloxacin), all aminoglycosides, and a polypeptide. Twenty-one (18%) isolates did not have DST reports for all first-line drugs; 4 (3%) did not have DST reports for any second-line drugs; 9 (8%) did not have DST reports for a fluoroquinolone; and 31 (26%) did not have DST reports for all second-line aminoglycosides and polypeptide.
Conclusion: Inconsistencies were observed in several of the 118 DST reports. A case is made for sensitization toward standardization and completeness in TB DST reporting in India.
Databáze: MEDLINE
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