Synthesis of ribosyl-ribosyl-adenosine-5',5'',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose).

Autor: Liu Q; Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. filippov@chem.leidenuniv.nl., Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Sep 14; Vol. 53 (74), pp. 10255-10258.
DOI: 10.1039/c7cc05755e
Abstrakt: Poly-adenosine diphosphate ribose (PAR) is a branched biopolymer that occurs as a result of post-translational modification of proteins. In 1981 Miwa et al. determined the structure of enzymatically prepared branched PAR. We present the first synthesis of the same branched PAR fragment and have shown by NMR that the structure proposed by Miwa is correct.
Databáze: MEDLINE