Diterpenoids from the roots of Croton dichogamus Pax.

Autor: Aldhaher A; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom; Department of Biology, College of Science, Basrah University, Basrah, Iraq., Langat M; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom; School of Chemistry and Physics, University of Natal, Durban, 4041, South Africa., Ndunda B; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom; Department of Chemistry, University of Nairobi, P Bag 30197-00100, Nairobi, Kenya., Chirchir D; Department of Chemistry, Egerton University, P.O. Box 536, Njoro, 20115, Kenya., Midiwo JO; Department of Chemistry, University of Nairobi, P Bag 30197-00100, Nairobi, Kenya., Njue A; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom; Department of Chemistry, Egerton University, P.O. Box 536, Njoro, 20115, Kenya., Schwikkard S; Department of Chemistry, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston, KT1 2EE, United Kingdom., Carew M; Department of Chemistry, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston, KT1 2EE, United Kingdom., Mulholland D; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom; School of Chemistry and Physics, University of Natal, Durban, 4041, South Africa. Electronic address: d.mulholland@surrey.ac.uk.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2017 Dec; Vol. 144, pp. 1-8. Date of Electronic Publication: 2017 Sep 01.
DOI: 10.1016/j.phytochem.2017.08.014
Abstrakt: Four previously undescribed diterpenoids including two crotofolanes, crotodichogamoin A and B, and two halimanes, crothalimene A and B, a new sesquiterpenoid, and fifteen previously reported compounds, including the crotofolane, crotohaumanoxide, the casbane, depressin, a further seven furanohalimane diterpenoids, three patchoulane and two further cadinane sesquiterpenoids and aleuritolic acid were isolated from the root of Croton dichogamus. Crotodichogamoin B is an important biosynthetic intermediate of the crotofolane class and this is the first report of patchoulene sesquiterpenoids from the genus. Compounds were tested at one concentration, 1 × 10 -5  M, in the NCI59 cell one-dose screen but did not show significant activity snd were also evaluated for their cytotoxicity against Caco-2 cell lines using the neutral red assay. 10-epi-Maninsigin D reduced Caco-2 cell viability at 10, 30 and 100 μM, with values of decreased viability of 28%, 48% and 43% respectively. None of the other tested compounds showed significant activity.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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