| Autor: |
Adebayo GI, Oyenuga AB, Mabadeje AF |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 1987 Feb; Vol. 14 (2), pp. 103-9. |
| DOI: |
10.1111/j.1440-1681.1987.tb00963.x |
| Abstrakt: |
The effect of beta-adrenoceptor blockers on the absorption and elimination of the diuretic chlorothiazide was studied in healthy subjects. A week of pretreatment with either pindolol (10 mg twice daily) or propranolol (80 mg twice daily) resulted in significant reduction in 36 h mean cumulative urinary recovery of chlorothiazide in two groups of six subjects compared with a control (untreated) group. A week of pretreatment with atenolol (100 mg daily) did not significantly alter 36 h cumulative urinary excretion in another group of six subjects. None of the beta-blockers significantly changed chlorothiazide half-life. It is suggested that the non-selective (as opposed to the cardioselective) beta-blockers reduce chlorothiazide absorption by the mechanism(s) discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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