Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells.

Autor: Bandoła J; Department of Pediatrics, University Clinic Dresden, Dresden, Germany., Richter C; Department of Pediatrics, University Clinic Dresden, Dresden, Germany., Ryser M; Department of Pediatrics, University Clinic Dresden, Dresden, Germany., Jamal A; Department of Pediatrics, University Clinic Dresden, Dresden, Germany.; Department of Medical Laboratory Sciences, Imperial College of Business Studies, Lahore, Pakistan., Ashton MP; DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, Germany., von Bonin M; Medical Clinic I, University Clinic Dresden, Dresden, Germany.; DKTK-German Cancer Consortium, Partner Site Dresden, University Clinic Dresden, Dresden, Germany.; DKFZ-German Cancer Research Center, Heidelberg, Germany., Kuhn M; Faculty of Medicine, Institute for Medical Informatics and Biometry, Technische Universitaet Dresden, Dresden, Germany., Dorschner B; Department of Pediatrics, University Clinic Dresden, Dresden, Germany., Alexopoulou D; BIOTEChnology Center/DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, Germany., Navratiel K; Department of Pediatrics, University Clinic Dresden, Dresden, Germany., Roeder I; Faculty of Medicine, Institute for Medical Informatics and Biometry, Technische Universitaet Dresden, Dresden, Germany., Dahl A; BIOTEChnology Center/DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, Germany., Hedrich CM; Department of Pediatrics, University Clinic Dresden, Dresden, Germany., Bonifacio E; DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, Germany., Brenner S; Department of Pediatrics, University Clinic Dresden, Dresden, Germany.; DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, Germany., Thieme S; Department of Pediatrics, University Clinic Dresden, Dresden, Germany.
Jazyk: angličtina
Zdroj: Frontiers in immunology [Front Immunol] 2017 Aug 17; Vol. 8, pp. 981. Date of Electronic Publication: 2017 Aug 17 (Print Publication: 2017).
DOI: 10.3389/fimmu.2017.00981
Abstrakt: Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin receptor p75 neurotrophin receptor (p75NTR) by the antigen-presenting pDCs, mediated by toll-like receptor (TLR) 9 activation and differential phosphorylation of interferon regulatory factor 3 and 7. The modulation of p75NTR on pDCs significantly influences disease progression of asthma in an ovalbumin-induced mouse model mediated by the TLR9 signaling pathway. p75NTR activation of pDCs from patients with asthma increased allergen-specific T cell proliferation and cytokine secretion in nerve growth factor concentration-dependent manner. Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model. Thus, p75NTR signaling on pDCs constitutes a new and critical mechanism connecting neurotrophin signaling and immune response regulation with great therapeutic potential for a variety of immune disorders.
Databáze: MEDLINE