Effect of CRP value on 18 F-FDG PET vascular positivity in Takayasu arteritis: a systematic review and per-patient based meta-analysis.

Autor: Gomez L; Department of Biophysics and Nuclear Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France., Chaumet-Riffaud P; Department of Biophysics and Nuclear Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France., Noel N; Department of Internal Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France.; Université Paris Sud, Le Kremlin Bicêtre, France.; INSERM UMR 1184, Immunologie des Maladies Virales et Autoimmunes (IMVA), Université Paris Sud, Le Kremlin Bicêtre, France.; CEA, DSV/iMETI, Division of Immuno-Virology IDMIT, Paris, France., Lambotte O; Department of Internal Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France.; Université Paris Sud, Le Kremlin Bicêtre, France.; INSERM UMR 1184, Immunologie des Maladies Virales et Autoimmunes (IMVA), Université Paris Sud, Le Kremlin Bicêtre, France.; CEA, DSV/iMETI, Division of Immuno-Virology IDMIT, Paris, France., Goujard C; Department of Internal Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France.; Université Paris Sud, Le Kremlin Bicêtre, France.; CEA, DSV/iMETI, Division of Immuno-Virology IDMIT, Paris, France.; INSERM U1018, CESP, Le Kremlin Bicêtre, France., Durand E; Department of Biophysics and Nuclear Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France.; Université Paris Sud, Le Kremlin Bicêtre, France.; IR4M - UMR8081, Université Paris Sud, Université Paris Saclay, CNRS, 91404, Orsay, France., Besson FL; Department of Biophysics and Nuclear Medicine, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin-Bicêtre, France. florent.besson@aphp.fr.; Université Paris Sud, Le Kremlin Bicêtre, France. florent.besson@aphp.fr.; IR4M - UMR8081, Université Paris Sud, Université Paris Saclay, CNRS, 91404, Orsay, France. florent.besson@aphp.fr.
Jazyk: angličtina
Zdroj: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2018 Apr; Vol. 45 (4), pp. 575-581. Date of Electronic Publication: 2017 Aug 30.
DOI: 10.1007/s00259-017-3798-x
Abstrakt: Purpose: The aim of this study was to quantify the association between the CRP value and 18 F-FDG PET vascular positivity in Takayasu arteritis (TAK) through a structured dedicated systematic review and meta-analysis.
Methods: From January 2000 to December 2016, the PubMed/MEDLINE database was searched for articles specifically dealing with the assessment of vascular inflammation using 18 F-FDG PET and CRP biomarkers in TAK. Inclusion criteria for the qualitative analysis were (1) 18 F-FDG PET used to assess the disease activity, (2) The use of the ACR criteria for the diagnosis of TAK, (3) No case mixed vasculitis (i.e., no giant cell arteritis), and (4) CRP concentration and clinical disease activity available. For the meta-analysis, PET-positive and PET-negative subgroups with the corresponding CRP concentrations were generated based on per patient data. The standard mean difference, which represents the effect of the CRP concentrations on the 18 F-FDG PET vascular uptake, was computed for all studies, and then the results were pooled together.
Results: Among the 33 initial citations, nine complete articles including 210 patients fulfilled the inclusion criteria. Five studies found a significant correlation between the 18 F-FDG PET and CRP concentration, one provided a trend towards association and three did not find any association between the two biomarkers. Six studies found a significant association between 18 F-FDG PET and clinical disease activity, one found a trend towards association and the last two studies did not evaluate this correlation. The meta-analysis (121 patients) provided the following results: Standard Mean Deviation = 0.54 [0.15;0.92]; Chi 2  = 3.35; I 2  = 0%; Test for overall effect: Z = 2.70 (P = 0.007).
Conclusion: The CRP concentration only moderately reflects the 18 F-FDG PET vascular positivity in TAK, suggesting dissociated information. Standardized longitudinal prospective studies are necessary to assess the value of 18 F-FDG PET as an independent biomarker for subtle vascular wall inflammation detection.
Databáze: MEDLINE
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