Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study.

Autor:	Felício JS; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., de Oliveira AF; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Peixoto AS; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., de Souza ACCB; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Abrahão Neto JF; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., de Melo FTC; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Carvalho CT; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., de Lemos MN; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Cavalcante SDN; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Resende FS; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Dos Santos MC; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Motta AR; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Janaú LC; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Yamada ES; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil., Felício KM; University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2017 Aug 14; Vol. 8, pp. 199. Date of Electronic Publication: 2017 Aug 14 (Print Publication: 2017).
DOI:	10.3389/fendo.2017.00199
Abstrakt:	Background: Some studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD. Methods: 22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient's previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation. Results: There was a reduction of DKD prevalence at the end of the study (68 vs 32%; p  = 0.05), with no changes on insulin doses, glycated hemoglobin, glycemic variability and blood pressure values. A correlation between percentage variation of VD levels (ΔVD) and albuminuria at the end of the study was presented ( r  = -0.5; p  < 0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes ( p  < 0.05). Conclusion: Our pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.
Databáze:	MEDLINE
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