Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil.

Autor:	Styczynski AR; National Center for Emerging Zoonotic and Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Malta JMAS; Program for Control and Prevention of Malaria and Diseases Transmitted by Aedes, Brazil Ministry of Health, Brasília, Federal District, Brazil., Krow-Lucal ER; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Percio J; Department of Communicable Disease Surveillance, Brazil Ministry of Health, Brasília, Federal District, Brazil., Nóbrega ME; Department of Communicable Disease Surveillance, Brazil Ministry of Health, Brasília, Federal District, Brazil., Vargas A; Department of Communicable Disease Surveillance, Brazil Ministry of Health, Brasília, Federal District, Brazil., Lanzieri TM; National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Leite PL; Program for Control and Prevention of Malaria and Diseases Transmitted by Aedes, Brazil Ministry of Health, Brasília, Federal District, Brazil., Staples JE; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Fischer MX; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Powers AM; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Chang GJ; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Burns PL; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Borland EM; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Ledermann JP; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Mossel EC; National Center for Emerging Zoonotic and Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America., Schonberger LB; National Center for Emerging Zoonotic and Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Belay EB; National Center for Emerging Zoonotic and Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Salinas JL; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Badaro RD; Federal University of Bahia, Complexo Hospitalar Edgard Santos, Salvador, Bahia, Brazil., Sejvar JJ; National Center for Emerging Zoonotic and Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Coelho GE; Department of Communicable Disease Surveillance, Brazil Ministry of Health, Brasília, Federal District, Brazil.
Jazyk:	angličtina
Zdroj:	PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2017 Aug 30; Vol. 11 (8), pp. e0005869. Date of Electronic Publication: 2017 Aug 30 (Print Publication: 2017).
DOI:	10.1371/journal.pntd.0005869
Abstrakt:	In mid-2015, Salvador, Brazil, reported an outbreak of Guillain-Barré syndrome (GBS), coinciding with the introduction and spread of Zika virus (ZIKV). We found that GBS incidence during April-July 2015 among those ≥12 years of age was 5.6 cases/100,000 population/year and increased markedly with increasing age to 14.7 among those ≥60 years of age. We conducted interviews with 41 case-patients and 85 neighborhood controls and found no differences in demographics or exposures prior to GBS-symptom onset. A higher proportion of case-patients (83%) compared to controls (21%) reported an antecedent illness (OR 18.1, CI 6.9-47.5), most commonly characterized by rash, headache, fever, and myalgias, within a median of 8 days prior to GBS onset. Our investigation confirmed an outbreak of GBS, particularly in older adults, that was strongly associated with Zika-like illness and geo-temporally associated with ZIKV transmission, suggesting that ZIKV may result in severe neurologic complications.
Databáze:	MEDLINE
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