Candidate genes for male and female reproductive traits in Canchim beef cattle.

Autor: Buzanskas ME; Departamento de Zootecnia, Universidade Federal da Paraíba (UFPB), Areia, Paraíba 58397-000 Brazil., Grossi DDA; Fast Genetics, Saskatoon, SK S7K 2K6 Canada., Ventura RV; Beef Improvement Opportunities (BIO), Guelph, ON N1K 1E5 Canada., Schenkel FS; Department of Animal and Poultry Science, University of Guelph, Centre for Genetic Improvement of Livestock (CGIL), Guelph, ON N1G 2W1 Canada., Chud TCS; Departamento de Ciências Exatas, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, São Paulo 14884-900 Brazil., Stafuzza NB; Departamento de Ciências Exatas, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, São Paulo 14884-900 Brazil., Rola LD; Departamento de Zootecnia, Núcleo de Pesquisa e Conservação de Cervídeos, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, São Paulo 14884-900 Brazil., Meirelles SLC; Department of Animal Science, Federal University of Lavras (UFLA), Lavras, Minas Gerais 37200-000 Brazil., Mokry FB; Department of Genetics and Evolution, Federal University of São Carlos (UFSCar), São Carlos, São Paulo 13565-905 Brazil., Mudadu MA; Embrapa Agricultural Informatics, Campinas, São Paulo 13083-886 Brazil., Higa RH; Embrapa Agricultural Informatics, Campinas, São Paulo 13083-886 Brazil., da Silva MVGB; Embrapa Dairy Cattle, Juiz de Fora, Minas Gerais 36038-330 Brazil., de Alencar MM; Embrapa Southeast Livestock, São Carlos, São Paulo 13560-970 Brazil., Regitano LCA; Embrapa Southeast Livestock, São Carlos, São Paulo 13560-970 Brazil., Munari DP; Departamento de Ciências Exatas, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, São Paulo 14884-900 Brazil.
Jazyk: angličtina
Zdroj: Journal of animal science and biotechnology [J Anim Sci Biotechnol] 2017 Aug 23; Vol. 8, pp. 67. Date of Electronic Publication: 2017 Aug 23 (Print Publication: 2017).
DOI: 10.1186/s40104-017-0199-8
Abstrakt: Background: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals.
Results: Associated SNPs were observed for scrotal circumference at 420 d of age (435 SNPs), followed by scrotal circumference at 210 d of age (12 SNPs), age at first calving (six SNPs), and age at second calving (four SNPs). We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and reproduction.
Conclusions: Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless, the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, all relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.
Databáze: MEDLINE
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