| Autor: |
Ernstbrunner M; Department of Anaesthesiology and Critical Care Medicine, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Kabon B; Department of Anaesthesiology and Critical Care Medicine, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Zotti O; Department of Anaesthesiology and Critical Care Medicine, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Zeitlinger M; Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Berner C; Kaiser-Franz-Josef Spital -Sozialmedizinisches Zentrum Süd- Medical Department I, Kundratstraße 3, A-1100, Vienna, Austria., Hinterholzer G; Kaiser-Franz-Josef Spital -Sozialmedizinisches Zentrum Süd- Medical Department I, Kundratstraße 3, A-1100, Vienna, Austria., Säemann M; Department of Internal Medicine III, Clinical Division of Nephrology & Dialysis, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Frommlet F; Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Fleischmann E; Department of Anaesthesiology and Critical Care Medicine, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria., Hecking M; Department of Internal Medicine III, Clinical Division of Nephrology & Dialysis, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria. manfred.hecking@meduniwien.ac.at. |
| Abstrakt: |
The effects of intravenous fluid therapy on fluid compartments and hemodynamics of the human body remain enigmatic. We therefore tested the efficacy of bioimpedance spectroscopy in a crossover study, where 15 males received 0.5 ml/kg/min ELO-MEL-isoton (osmolarity = 302 mosmol/l) during 60 minutes, or nothing at all. In group "Fluid", fluid load increased from -0.2 ± 1.0 l extracellular volume at baseline to its maximum of 1.0 ± 0.9 l in minute 70, and remained continuously elevated throughout minute 300. In group "Zero", fluid load decreased from 0.5 ± 1.1 l at baseline to its minimum of -1.1 ± 1.1 l in minute 300. In group "Fluid", intracellular volume decreased from 26.8 ± 3.9 l at baseline to its minimum of 26.0 ± 3.9 l in minute 70, and remained continuously decreased throughout minute 300. In group "Zero", intracellular volume increased from 26.5 ± 3.8 l at baseline to its maximum of 27.1 ± 3.9 l in minute 120, and decreased thereafter. In group "Fluid" compared to "Zero", systolic blood pressure was significantly higher, from minute 50-90. In conclusion, intravenous fluid therapy caused a clinically meaningful, sustained increase in fluid load, and a decrease in intracellular volume. These data raise interest in studying fluid administration by the gastrointestinal route, perhaps even when managing critical illness. |
