Increasing suppression of saccade-related transients along the human visual hierarchy.

Autor: Golan T; Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Davidesco I; Department of Psychology, New York University, New York, United States., Meshulam M; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel., Groppe DM; Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, United States.; The Feinstein Institute for Medical Research, Manhasset, United States.; The Krembil Neuroscience Centre, Toronto, Canada., Mégevand P; Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, United States.; The Feinstein Institute for Medical Research, Manhasset, United States., Yeagle EM; Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, United States.; The Feinstein Institute for Medical Research, Manhasset, United States., Goldfinger MS; Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, United States.; The Feinstein Institute for Medical Research, Manhasset, United States., Harel M; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel., Melloni L; Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, Germany.; NYU Comprehensive Epilepsy Center, Department of Neurology, School of Medicine, New York University, New York, United States., Schroeder CE; Department of Neurosurgery, Columbia University College of Physicians and Surgeons, New York, United States.; Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, United States., Deouell LY; Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel., Mehta AD; Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, United States.; The Feinstein Institute for Medical Research, Manhasset, United States., Malach R; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Jazyk: angličtina
Zdroj: ELife [Elife] 2017 Aug 29; Vol. 6. Date of Electronic Publication: 2017 Aug 29.
DOI: 10.7554/eLife.27819
Abstrakt: A key hallmark of visual perceptual awareness is robustness to instabilities arising from unnoticeable eye and eyelid movements. In previous human intracranial (iEEG) work (Golan et al., 2016) we found that excitatory broadband high-frequency activity transients, driven by eye blinks, are suppressed in higher-level but not early visual cortex. Here, we utilized the broad anatomical coverage of iEEG recordings in 12 eye-tracked neurosurgical patients to test whether a similar stabilizing mechanism operates following small saccades. We compared saccades (1.3°-3.7°) initiated during inspection of large individual visual objects with similarly-sized external stimulus displacements. Early visual cortex sites responded with positive transients to both conditions. In contrast, in both dorsal and ventral higher-level sites the response to saccades (but not to external displacements) was suppressed. These findings indicate that early visual cortex is highly unstable compared to higher-level visual regions which apparently constitute the main target of stabilizing extra-retinal oculomotor influences.
Databáze: MEDLINE
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