DNA replication through a chromatin environment.
| Autor: | Bellush JM; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.; BCMB Graduate Program, Weill Cornell Medical College, 1300 York Avenue, New York, NY, USA., Whitehouse I; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA whitehoi@mskcc.org. |
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| Jazyk: | angličtina |
| Zdroj: | Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2017 Oct 05; Vol. 372 (1731). |
| DOI: | 10.1098/rstb.2016.0287 |
| Abstrakt: | Compaction of the genome into the nuclear space is achieved by wrapping DNA around octameric assemblies of histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. Aside from providing a means by which to fit larger genomes into the cell, chromatinization of DNA is a crucial means by which the cell regulates access to the genome. While the complex role that chromatin plays in gene transcription has been appreciated for a long time, it is now also apparent that crucial aspects of DNA replication are linked to the biology of chromatin. This review will focus on recent advances in our understanding of how the chromatin environment influences key aspects of DNA replication.This article is part of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'. (© 2017 The Author(s).) |
| Databáze: | MEDLINE |
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