Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation.

Autor:	Tamimi EA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Pyne JD; Department of Mechanical Engineering, University of California Berkeley, Berkeley, California, United States., Muli DK; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Axman KF; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Howerton SJ; Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona, United States., Davis MR; Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona, United States., Girkin CA; Department of Ophthalmology, University of Alabama Birmingham, Birmingham, Alabama, United States., Vande Geest JP; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Louis J. Fox Center for Vision Restoration, University of Pittsburgh, Pennsylvania, United States.
Jazyk:	angličtina
Zdroj:	Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2017 Aug 01; Vol. 58 (10), pp. 4235-4246.
DOI:	10.1167/iovs.17-22141
Abstrakt:	Purpose: The purpose of this study was to quantify the biomechanical response of human posterior ocular tissues from donors of various racioethnic groups to better understand how differences in these properties may play a role in the racioethnic health disparities known to exist in glaucoma. Methods: Sequential digital image correlation (S-DIC) was used to measure the pressure-induced surface deformations of 23 normal human posterior poles from three racioethnic groups: African descent (AD), European descent (ED), and Hispanic ethnicity (HIS). Regional in-plane principal strains were compared across three zones: the optic nerve stump (ONS), the peripapillary (PP) sclera, and non-PP sclera. Results: The PP scleral tensile strains were found to be lower for ED eyes compared with AD and HIS eyes at 15 mm Hg (P = 0.024 and 0.039, respectively). The mean compressive strains were significantly higher for AD eyes compared with ED eyes at 15 mm Hg (P = 0.018). We also found that the relationship between tensile strain and pressure was significant for those of ED and HIS eyes (P < 0.001 and P = 0.004, respectively), whereas it was not significant for those of AD (P = 0.392). Conclusions: Our results suggest that, assuming glaucomatous nerve loss is caused by mechanical strains in the vicinity of the optic nerve head, the mechanism of increased glaucoma prevalence may be different in those of AD versus HIS. Our ONS strain analysis also suggested that it may be important to account for ONS geometry and material properties in future scleral biomechanical analysis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu