Acylcarnitines profile best predicts survival in horses with atypical myopathy.

Autor: Boemer F; Biochemical Genetics Laboratory, CHU Sart Tilman, University of Liege, Liege, Belgium., Detilleux J; Department of animal Productions: Biostatistics, Economy and animal selection, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liege, Belgium., Cello C; Biochemical Genetics Laboratory, CHU Sart Tilman, University of Liege, Liege, Belgium., Amory H; Equine Pole, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liege, Belgium., Marcillaud-Pitel C; Réseau d'EpidémioSurveillance en Pathologie Equine (RESPE), Caen, France., Richard E; Normandie Université, UNICAEN, Labéo Frank Duncombe, Caen, France., van Galen G; Equine Pole, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liege, Belgium., van Loon G; Large Animal Internal Medicine, Gent University, Gent, Belgium., Lefère L; Large Animal Internal Medicine, Gent University, Gent, Belgium., Votion DM; Equine Pole, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liege, Belgium.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2017 Aug 28; Vol. 12 (8), pp. e0182761. Date of Electronic Publication: 2017 Aug 28 (Print Publication: 2017).
DOI: 10.1371/journal.pone.0182761
Abstrakt: Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.
Databáze: MEDLINE
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