Selective Laser Trabeculoplasty vs. Fixed Combinations with Timolol in Practice: A Replacement Study in Primary Open Angle Glaucoma.
Autor: | Tufan AK; Health Sciences University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey., Onur İU; Health Sciences University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey., Yiğit FU; Health Sciences University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey., Ağaçhan A; Health Sciences University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey., Aşık Nacaroğlu Ş; Health Sciences University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey. |
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Jazyk: | angličtina |
Zdroj: | Turkish journal of ophthalmology [Turk J Ophthalmol] 2017 Aug; Vol. 47 (4), pp. 198-204. Date of Electronic Publication: 2017 Aug 15. |
DOI: | 10.4274/tjo.87300 |
Abstrakt: | Objectives: To evaluate the potential of selective laser trabeculoplasty (SLT) in two arms (360˚ vs. 180˚) as a replacement for fixed combinations (FCs) with timolol in primary open angle glaucoma over 6 months. Materials and Methods: Of 40 patients in a prospective, comparative, interventional case series, 18 eyes and 22 eyes were randomized to SLT 180º and SLT 360º groups, respectively, along with 40 fellow-control eyes. FC with timolol was discontinued on the day of treatment for the eye to be operated on, while ongoing therapy was not interrupted for the contralateral eye. Eyes were examined for intraocular pressure (IOP) elevation 1 hour and 1 day after SLT. The follow-up visits were then scheduled for 1 week, 1 month, 3 months, and 6 months after, during the which the IOP of both eyes and any possible complications were evaluated. Results: There were no statistically significant differences in mean IOPs through 6 months among the groups with exception of postlaser 1 hour and postlaser 1 day (p<0.001 and p=0.010, respectively). Multiple comparison analysis showed significantly higher IOP in both SLT 180º and SLT 360º subgroups compared to their controls at postlaser 1 hour (p=0.007, p<0.001) but significantly lower IOP only in SLT 360º subgroup compared to the controls at postlaser day 1 (p=0.013). Conclusion: SLT offers promising potential as a substitute equivalent to efficacy of FCs with timolol. However, SLT 360˚ may not achieve additional IOP reduction. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. |
Databáze: | MEDLINE |
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