What is MR spectroscopy?
| Autor: | Manias KA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, West Midlands, UK.; Department of Paediatric Oncology, Birmingham Children's Hospital, Birmingham, West Midlands, UK., Peet A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, West Midlands, UK.; Department of Paediatric Oncology, Birmingham Children's Hospital, Birmingham, West Midlands, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Archives of disease in childhood. Education and practice edition [Arch Dis Child Educ Pract Ed] 2018 Aug; Vol. 103 (4), pp. 213-216. Date of Electronic Publication: 2017 Aug 26. |
| DOI: | 10.1136/archdischild-2017-312839 |
| Abstrakt: | 1 H-Magnetic Resonance Spectroscopy (MRS) is a novel advanced imaging technique used as an adjunct to MRI to reveal complementary non-invasive information about the biochemical composition of imaged tissue. Clinical uses in paediatrics include aiding diagnosis of brain tumours, neonatal disorders such as hypoxic-ischaemic encephalopathy, inherited metabolic diseases, traumatic brain injury, demyelinating conditions and infectious brain lesions. MRS has potential to improve diagnosis and treatment monitoring of childhood brain tumours and other CNS diseases, facilitate biopsy and surgical planning, and provide prognostic biomarkers. MRS is employed as a research tool outside the brain in liver disease and disorders of muscle metabolism. The range of clinical uses is likely to increase with growing evidence for added value. Multicentre trials are needed to definitively establish the benefits of MRS in specific clinical scenarios and integrate this promising new technique into routine practice to improve patient care. This article gives a brief overview of MRS and its potential clinical applications, and addresses challenges surrounding translation into practice. Competing Interests: Competing interests: None declared. (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.) |
| Databáze: | MEDLINE |
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