The Beneficial Effect of Anthocyanidin-Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High-Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions.

Autor: da Costa GF; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Santos IB; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., de Bem GF; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Cordeiro VSC; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., da Costa CA; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., de Carvalho LCRM; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Ognibene DT; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Resende AC; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., de Moura RS; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2017 Oct; Vol. 31 (10), pp. 1621-1632. Date of Electronic Publication: 2017 Aug 25.
DOI: 10.1002/ptr.5898
Abstrakt: We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue. These beneficial effects of GSE may be related to a positive modulation of insulin signaling proteins (IR, pIRS, PI3K, pAKT), pAMPK/AMPK ratio, and GLUT4 expression in muscle and adipose tissue. In addition, GSE prevented the oxidative damage, evidenced by the restoration of antioxidant activity and decrease of malondialdehyde and carbonyl levels in muscle and adipose tissue. Finally, GSE showed an anti-inflammatory action, evidenced by the reduced plasma and adipose tissue inflammatory markers (TNF-α, IL-6). Our results suggest that GSE prevented the obesity and related metabolic disorders in HF-fed mice by regulating insulin sensitivity and GLUT4 expression as well as by preventing the oxidative stress and inflammation in skeletal muscle and adipose tissue. Copyright © 2017 John Wiley & Sons, Ltd.
(Copyright © 2017 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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