Acute respiratory infections in hospitalized children in Vientiane, Lao PDR - the importance of Respiratory Syncytial Virus.

Autor: Nguyen VH; UMR 'Emergence des Pathologies Virales' (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France.; Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France.; Department of Infectious Diseases, Hai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam., Dubot-Pérès A; UMR 'Emergence des Pathologies Virales' (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France. audrey@tropmedres.ac.; Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France. audrey@tropmedres.ac.; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR. audrey@tropmedres.ac.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford, Oxford, United Kingdom. audrey@tropmedres.ac., Russell FM; Dept. of Paediatrics, The University of Melbourne, Melbourne, Australia.; Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Australia., Dance DAB; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford, Oxford, United Kingdom.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Vilivong K; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR., Phommachan S; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR., Syladeth C; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR., Lai J; Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Australia.; National Centre for Epidemiology & Population Health, Australian National University, Canberra, Australia., Lim R; Pneumococcal Research Group, Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Australia., Morpeth M; Dept. of Paediatrics, The University of Melbourne, Melbourne, Australia.; The Royal Children's Hospital, Melbourne, Australia., Mayxay M; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR.; Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Lao PDR, Vientiane, Laos., Newton PN; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Vientiane, Lao PDR.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford, Oxford, United Kingdom., Richet H; UMR 'Emergence des Pathologies Virales' (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France., De Lamballerie X; UMR 'Emergence des Pathologies Virales' (EPV: Aix-Marseille university - IRD190 - Inserm 1207 - EHESP), Marseille, France.; Institut hospitalo-universitaire Méditerranée infection, APHM Public Hospitals of Marseille, Marseille, France.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Aug 24; Vol. 7 (1), pp. 9318. Date of Electronic Publication: 2017 Aug 24.
DOI: 10.1038/s41598-017-09006-6
Abstrakt: The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD ® kit). A total of 383 patients were included, 277 (72.3%) of whom presented with pneumonia. 377 (98.4%) patients were positive for at least one microorganism, of which RSV was the most common virus (41.0%), with a peak observed between June and September, corresponding to the rainy season. Most RSV inpatients had pneumonia (84.1%), of whom 35% had severe pneumonia. Children <3-months old were a high-risk group for severe pneumonia, independently of RSV infection. Our study suggests that RSV infection is frequent in Laos and commonly associated with pneumonia in hospitalized young children. Further investigations are required to provide a better overall view of the Lao nationwide epidemiology and public health burden of RSV infection over time.
Databáze: MEDLINE
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