Mitochondrial DNA analysis of Tunisians reveals a mosaic genetic structure with recent population expansion.

Autor: Frigi S; Laboratory of Molecular Genetics, Immunology and Human Pathology at the Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia., Mota-Vieira L; Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPER, Avenida D. Manuel I, 9500-370 Ponta Delgada, São Miguel Island, Azores, Portugal; Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisboa, Campo Grande, 1749-016 Lisboa, Portugal; Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal. Electronic address: Luisa.MQ.Vieira@azores.gov.pt., Cherni L; Laboratory of Molecular Genetics, Immunology and Human Pathology at the Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia; Higher Institute of Biotechnology of Monastir, University of Monastir, 5000 Monastir, Tunisia., van Oven M; Turkooislaan 60, 3523 GN Utrecht, The Netherlands., Pires R; Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPER, Avenida D. Manuel I, 9500-370 Ponta Delgada, São Miguel Island, Azores, Portugal., Boussetta S; Laboratory of Molecular Genetics, Immunology and Human Pathology at the Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia., El-Gaaied ABA; Laboratory of Molecular Genetics, Immunology and Human Pathology at the Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia.
Jazyk: angličtina
Zdroj: Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen [Homo] 2017 Aug; Vol. 68 (4), pp. 298-315. Date of Electronic Publication: 2017 May 19.
DOI: 10.1016/j.jchb.2017.05.003
Abstrakt: Tunisia is a country of great interest for human population genetics due to its strategic geographic position and rich human settlement history. These factors significantly contributed to the genetic makeup of present-day Tunisians harbouring components of diverse geographic origins. Here, we investigated the genetic structure of Tunisians by performing a mitochondrial DNA (mtDNA) comparison of 15 Tunisian population groups, in order to explore their complex genetic landscape. All Tunisian data were also analysed against 40 worldwide populations. Statistical results (Tajima's D and Fu's F S tests) suggested recent population expansion for the majority of studied populations, as well as showed (AMOVA test) that all populations were significantly different from each other, which is evidence of population structure even if it is not guided by geographic and ethnic effects. Gene flow analysis revealed the assignment of Tunisians to multiple ancestries, which agrees with their genetic heterogeneity. The resulting picture for the mtDNA pool confirms the evidence of a recent expansion of the Tunisian population and is in accordance with a mosaic structure, composed by North African, Middle Easterner, European and Sub-Saharan lineages, resulting from a complex settlement history.
(Copyright © 2017 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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