Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy.

Autor:	Henrich TJ; Division of Experimental Medicine, University of California, San Francisco.; Division of Infectious Diseases, Brigham and Women's Hospital.; Harvard Medical School., Hobbs KS; Division of Experimental Medicine, University of California, San Francisco.; Division of Infectious Diseases, Brigham and Women's Hospital., Hanhauser E; Division of Experimental Medicine, University of California, San Francisco.; Division of Infectious Diseases, Brigham and Women's Hospital., Scully E; Division of Infectious Diseases, Brigham and Women's Hospital.; Harvard Medical School.; Dana-Farber Cancer Institute, Boston., Hogan LE; Division of Experimental Medicine, University of California, San Francisco.; Division of Infectious Diseases, Brigham and Women's Hospital.; Harvard Medical School., Robles YP; Division of Infectious Diseases, Brigham and Women's Hospital., Leadabrand KS; Division of Experimental Medicine, University of California, San Francisco., Marty FM; Division of Infectious Diseases, Brigham and Women's Hospital.; Harvard Medical School.; Dana-Farber Cancer Institute, Boston., Palmer CD; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge., Jost S; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge.; Beth Israel Deaconess Medical Center., Körner C; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge., Li JZ; Division of Infectious Diseases, Brigham and Women's Hospital.; Harvard Medical School., Gandhi RT; Harvard Medical School.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge.; Massachusetts General Hospital, Boston., Hamdan A; Harvard Medical School.; Beth Israel Deaconess Medical Center., Abramson J; Harvard Medical School.; Massachusetts General Hospital, Boston., LaCasce AS; Harvard Medical School.; Dana-Farber Cancer Institute, Boston., Kuritzkes DR; Division of Infectious Diseases, Brigham and Women's Hospital.; Harvard Medical School.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2017 Jul 15; Vol. 216 (2), pp. 254-262.
DOI:	10.1093/infdis/jix265
Abstrakt:	Background: Systemic chemotherapies for various malignancies have been shown to significantly, yet transiently, decrease numbers of CD4+ T lymphocytes, a major reservoir for human immunodeficiency virus type 1 (HIV-1) infection. However, little is known about the impact of cytoreductive chemotherapy on HIV-1 reservoir dynamics, persistence, and immune responses. Methods: We investigated the changes in peripheral CD4+ T-cell-associated HIV-1 DNA and RNA levels, lymphocyte activation, viral population structure, and virus-specific immune responses in a longitudinal cohort of 15 HIV-1-infected individuals receiving systemic chemotherapy or subsequent autologous stem cell transplantation for treatment of hematological malignancies and solid tumors. Results: Despite a transient reduction in CD4+ T cells capable of harboring HIV-1, a 1.7- and 3.3-fold increase in mean CD4+ T-cell-associated HIV-1 RNA and DNA, respectively, were observed months following completion of chemotherapy in individuals on antiretroviral therapy. We also observed changes in CD4+ T-cell population diversity and clonal viral sequence expansion during CD4+ T-cell reconstitution following chemotherapy cessation. Finally, HIV-1 DNA was preferentially, and in some cases exclusively, detected in cytomegalovirus (CMV)- and Epstein-Barr virus (EBV)-responsive CD4+ T cells following chemotherapy. Conclusions: Expansion of HIV-infected CMV/EBV-specific CD4 + T cells may contribute to maintenance of the HIV DNA reservoir following chemotherapy. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu