Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvement.

Autor: Martins RD; Department of Nutrition, Federal University of Pernambuco, CAV, Vitória de Santo Antão, Pernambuco, Brazil., Jorge RJB; Department of Nutrition, Federal University of Pernambuco, CAV, Vitória de Santo Antão, Pernambuco, Brazil. Electronic address: robertajeanebj@gmail.com., Alves RS; Department of Clinical and Toxicological Analyses, Federal University of Ceará, Fortaleza, Ceará, Brazil., Silva Neto AGD; Department of Physiology and Pharmacology, Institute of Biomedicine and Clinical Research Unit, Federal University of Ceará, Fortaleza, Ceará, Brazil., Barbosa PSF; Veterinary Faculty, State University of Ceará, Fortaleza, Ceará, Brazil., Costa Martins AM; Department of Clinical and Toxicological Analyses, Federal University of Ceará, Fortaleza, Ceará, Brazil., Toyama MH; São Vicente Unit, Campus of Litoral Paulista, Paulista State University (UNESP), São Paulo, Brazil., Monteiro HSA; Department of Physiology and Pharmacology, Institute of Biomedicine and Clinical Research Unit, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2017 Nov; Vol. 138, pp. 78-81. Date of Electronic Publication: 2017 Aug 23.
DOI: 10.1016/j.toxicon.2017.08.019
Abstrakt: Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA 2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular effects of B. caissarum crude extract (BcE) on isolated perfused kidney and arteriolar mesenteric bed, as well the involvement of prostaglandins and endothelin. BcE did not show any effect on arteriolar mesenteric bed, but increased perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and decreased the percentage of sodium tubular transport on isolated perfused kidney. Indomethacin blocked the renal effects induced by BcE and tezosentan only partially blocked these effects. These results demonstrate the effects of BcE on kidney in situ, suggesting the involvement of prostaglandins and endothelin.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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