N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT.

Autor: Behrouzi Lak T; Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran., Hajshafiha M; Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran., Nanbakhsh F; Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran., Oshnouei S; Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran.
Jazyk: angličtina
Zdroj: International journal of reproductive biomedicine [Int J Reprod Biomed] 2017 Apr; Vol. 15 (4), pp. 203-208.
Abstrakt: Background: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance.
Objective: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination.
Materials and Methods: In this randomized clinical trial, 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1.2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, recombinant human follicle stimulating hormone (r-hFSH; Gonal-F®) was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, 10000 IU human chorionic gonadotropin was injected intramuscular and the intrauterine insemination was performed after 34-36 hr.
Results: There were not significant differences between study groups regarding mean endometrial thickness (p=0.14), the mean number of mature follicles (p=0.20), and the pregnancy rate (p=0.09).
Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients.
Competing Interests: It should be noted that there was no association between the authors and any organization or institution. The Authors report no declarations of interest.
Databáze: MEDLINE
Externí odkaz: