Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men.

Autor:	Chanet A; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Verlaan S; Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, Amsterdam, Netherlands., Salles J; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Giraudet C; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Patrac V; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Pidou V; University Hospital Clermont-Ferrand, Center for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Pouyet C; University of Clermont Auvergne, INRA, Human Nutrition Unit, Metabolism Exploration Platform, Clermont-Ferrand, France; and., Hafnaoui N; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Blot A; University Hospital Clermont-Ferrand, Center for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Cano N; University Hospital Clermont-Ferrand, Center for Research in Human Nutrition Auvergne, Clermont-Ferrand, France.; University Hospital Clermont-Ferrand, Clinical Nutrition Unit, Clermont-Ferrand, France., Farigon N; University Hospital Clermont-Ferrand, Clinical Nutrition Unit, Clermont-Ferrand, France., Bongers A; Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, Netherlands., Jourdan M; Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, Netherlands., Luiking Y; Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, Netherlands., Walrand S; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France., Boirie Y; University of Clermont Auvergne, INRA, Human Nutrition Unit, Centre for Research in Human Nutrition Auvergne, Clermont-Ferrand, France; yves.boirie@clermont.inra.fr.; University Hospital Clermont-Ferrand, Clinical Nutrition Unit, Clermont-Ferrand, France.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2017 Dec; Vol. 147 (12), pp. 2262-2271. Date of Electronic Publication: 2017 Aug 23.
DOI:	10.3945/jn.117.252510
Abstrakt:	Background: A promising strategy to help older adults preserve or build muscle mass is to optimize muscle anabolism through providing an adequate amount of high-quality protein at each meal. Objective: This "proof of principle" study investigated the acute effect of supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink on postprandial muscle protein synthesis and longer-term effect on muscle mass in healthy older adults. Methods: A randomized, placebo-controlled, double-blind study was conducted in 24 healthy older men [mean ± SD: age 71 ± 4 y; body mass index (in kg/m 2 ) 24.7 ± 2.8] between September 2012 and October 2013 at the Unit of Human Nutrition, University of Auvergne, Clermont-Ferrand, France. Participants received a medical nutrition drink [test group; 21 g leucine-enriched whey protein, 9 g carbohydrates, 3 g fat, 800 IU cholecalciferol (vitamin D 3 ), and 628 kJ] or a noncaloric placebo (control group) before breakfast for 6 wk. Mixed muscle protein fractional synthesis rate (FSR) was measured at week 0 in the basal and postprandial state, after study product intake with a standardized breakfast with the use of l-[ 2 H 5 ]-phenylalanine tracer methodology. The longer-term effect of the medical nutrition drink was evaluated by measurement of appendicular lean mass, representing skeletal muscle mass at weeks 0 and 6, by dual-energy X-ray absorptiometry. Results: Postprandial FSR (0-240 min) was higher in the test group than in the control group [estimate of difference (ED): 0.022%/h; 95% CI: 0.010%/h, 0.035%/h; ANCOVA, P = 0.001]. The test group gained more appendicular lean mass than the control group after 6 wk (ED: 0.37 kg; 95% CI: 0.03, 0.72 kg; ANCOVA, P = 0.035), predominantly as leg lean mass (ED: 0.30 kg; 95% CI: 0.03, 0.57 kg; ANCOVA, P = 0.034). Conclusions: Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink stimulated postprandial muscle protein synthesis and increased muscle mass after 6 wk of intervention in healthy older adults and may therefore be a way to support muscle preservation in older people. This trial was registered at www.trialregister.nl as NTR3471. Competing Interests: Author disclosures: AC, JS, CG, V Patrac, V Pidou, CP, NH, A Blot, NC, NF, SW, and YB, no conflicts of interest. SV, A Bongers, MJ, and YL are employees of the sponsor, Nutricia Research, Nutricia Advanced Medical Nutrition. (© 2017 American Society for Nutrition.)
Databáze:	MEDLINE
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