Polymer Based Protein Therapeutics.
| Autor: | Bhawani SA; Department of Chemistry, Faculty of Resource Science and Technology, UNIMAS, Sarawak, Malaysia., Husaini A; Department of Molecular Biology, Faculty of Resource Science and Technology, UNIMAS, Sarawak, Malaysia., Ahmad FB; Department of Chemistry, Faculty of Resource Science and Technology, UNIMAS, Sarawak, Malaysia., Asaruddin MR; Department of Chemistry, Faculty of Resource Science and Technology, UNIMAS, Sarawak, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | Current protein & peptide science [Curr Protein Pept Sci] 2018; Vol. 19 (10), pp. 972-982. |
| DOI: | 10.2174/1389203718666170821162823 |
| Abstrakt: | Proteins have played a very important role in the drug industry for developing treatments of various diseases such as auto-immune diseases, cancer, diabetes, mental disorder, metabolic disease, and others. Therapeutic proteins have high activity and specificity but they have some limitations such as short half-life, poor stability, low solubility and immunogenicity, so they cannot prolong their therapeutic activity. These shortcomings have been rectified by using polymers for the conjugation with proteins. The conjugates of protein-polymer improves the half-lives, stability and makes them non-immunogenic. Poly(ethylene glycol) (PEG), is widely used in the delivery of proteins because it is the current gold standard for stealth polymers in the emerging field of polymer-based delivery as compared to various biodegradable polymers. PEGylation enhances the retention of therapeutic proteins, effectively alters the pharmacokinetics and enhances the pharmaceutical value. Smart polymer have been used to cope with the pathophysiological environment of target site and have imposed less toxic effects.The contents of this article are challenges in formulation of therapeutic proteins, synthetic routes of conjugates, smart polymer-protein conjugates and also some advantages/disadvantages of polymers as a carrier system of proteins. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| Databáze: | MEDLINE |
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