Evidence for a role of plasma membrane calcium pumps in neurodegenerative disease: Recent developments.

Autor: Strehler EE; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Biomedicine, University of Basel, Basel, Switzerland. Electronic address: strehler.emanuel@mayo.edu., Thayer SA; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address: sathayer@umn.edu.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2018 Jan 10; Vol. 663, pp. 39-47. Date of Electronic Publication: 2017 Aug 19.
DOI: 10.1016/j.neulet.2017.08.035
Abstrakt: Plasma membrane Ca 2+ ATPases (PMCAs) are a major system for calcium extrusion from all cells. Different PMCA isoforms and splice variants are involved in the precise temporal and spatial handling of Ca 2+ signals and the re-establishment of resting Ca 2+ levels in the nervous system. Lack or inappropriate expression of specific PMCAs leads to characteristic neuronal phenotypes, which may be reciprocally exacerbated by genetic predisposition through alleles in other genes that modify PMCA interactions, regulation, and function. PMCA dysfunction is often poorly compensated in neurons and may lead to changes in synaptic transmission, altered excitability and, with long-term calcium overload, eventual cell death. Decrease and functional decline of PMCAs are hallmarks of neurodegeneration during aging, and mutations in specific PMCAs are responsible for neuronal dysfunction and accelerated neurodegeneration in many sensory and cognitive diseases.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: