Role of Electrocardiographic Tpeak-Tend for the Prediction of Ventricular Arrhythmic Events in the Brugada Syndrome.

Autor: Mugnai G; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium. Electronic address: mugnai.giacomo@gmail.com., Hunuk B; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Hernandez-Ojeda J; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Stroker E; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Velagic V; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Ciconte G; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., De Regibus V; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Coutino-Moreno HE; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Takarada K; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Choudhury R; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Abugattas de Torres JP; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Pappaert G; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Chierchia GB; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., Brugada P; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium., de Asmundis C; Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium.
Jazyk: angličtina
Zdroj: The American journal of cardiology [Am J Cardiol] 2017 Oct 15; Vol. 120 (8), pp. 1332-1337. Date of Electronic Publication: 2017 Jul 24.
DOI: 10.1016/j.amjcard.2017.07.014
Abstrakt: Some previous studies have proposed the electrocardiographic Tpeak-Tend (TpTe) as a possible predictor of ventricular arrhythmic events in patients with Brugada syndrome (BrS). We sought to analyze the association between the parameters of repolarization dispersion (TpTe, TpTe/QT, TpTe dispersion, QTc, and QTd) and ventricular fibrillation/sudden cardiac death in a large cohort of patients with type 1 BrS. A total of 448 consecutive patients with BrS (men 61%, age 45 ± 16 years) with spontaneous (n = 96, 21%) or drug-induced (n = 352, 79%) type 1 electrocardiogram were retrospectively included. At the time of the diagnosis or during a mean follow-up of 93 ± 47 months (median 88 months), 43 patients (9%) documented ventricular arrhythmias. No significant difference was observed in TpTe, TpTe/QT, maximum TpTe, and TpTe dispersion between asymptomatic patients and those with syncope and malignant arrhythmias. TpTe/QT ratio did not also significantly differ between patients with ventricular fibrillation/sudden cardiac death and those asymptomatic ones. In conclusion, TpTe was not significantly prolonged in those patients with type 1 BrS presenting with unexplained syncope or malignant arrhythmic events during follow-up.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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