Reduced dynamic range of antiviral innate immune responses in aging.

Autor: Molony RD; Departments of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, United States., Malawista A; Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States., Montgomery RR; Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States; Human Translational Immunology, Yale University School of Medicine, New Haven, CT 06520, United States. Electronic address: ruth.montgomery@yale.edu.
Jazyk: angličtina
Zdroj: Experimental gerontology [Exp Gerontol] 2018 Jul 01; Vol. 107, pp. 130-135. Date of Electronic Publication: 2017 Aug 16.
DOI: 10.1016/j.exger.2017.08.019
Abstrakt: The worldwide population aged≥65years is increasing and the average life span is expected to increase another 10years by 2050. This extended lifespan is associated with a progressive decline in immune function and a paradoxical state of low-grade, chronic inflammation that may contribute to susceptibility to viral infection, and reduced responses to vaccination. Here we review the effects of aging on innate immune responses to viral pathogens including elements of recognition, signaling, and production of inflammatory mediators. We specifically focus on age-related changes in key pattern recognition receptor signaling pathways, converging on altered cytokine responses, including a notable impairment of antiviral interferon responses. We highlight an emergent change in innate immunity that arises during aging - the dampening of the dynamic range of responses to multiple sources of stimulation - which may underlie reduced efficiency of immune responses in aging.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: