Effects of oxytocin and arginine vasopressin on the proliferation and differentiation of a serotonergic cell line.

Autor: Marinova Z; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland. Zoya.Marinova@barmelweid.ch., Walitza S; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland.; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zurich, Switzerland.; Zürich Center for Integrative Human Physiology, University of Zürich, Zurich, Switzerland., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland. edna.gruenblatt@kjpd.uzh.ch.; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zurich, Switzerland. edna.gruenblatt@kjpd.uzh.ch.; Zürich Center for Integrative Human Physiology, University of Zürich, Zurich, Switzerland. edna.gruenblatt@kjpd.uzh.ch.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2018 Jan; Vol. 125 (1), pp. 103-106. Date of Electronic Publication: 2017 Aug 18.
DOI: 10.1007/s00702-017-1778-8
Abstrakt: The neuropeptides oxytocin and arginine vasopressin (AVP) are involved in the regulation of social behavior and cognition. The current study analyzed the effect of oxytocin and AVP on proliferation and differentiation of serotonergic neurons (RN46A cells). Oxytocin did not affect, while 5-10 μM AVP decreased RN46A proliferation. Oxytocin did not significantly alter, while 10 μM AVP decreased the number of cells extending neurites. We found divergent effects of oxytocin and AVP in serotonergic neurons, underscoring their functional differences.
Databáze: MEDLINE
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