Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model.

Autor: Pierzynowski SG; Department of Biology, Lund University, 22362, Lund, Sweden. stefan.pierzynowski@biol.lu.se.; Innovation Centre - STB, 83110, Tczew, Poland. stefan.pierzynowski@biol.lu.se.; Anara, 23132, Trelleborg, Sweden. stefan.pierzynowski@biol.lu.se.; Department of Biology, Institute Rural Medicine, 20722, Lublin, Poland. stefan.pierzynowski@biol.lu.se., Goncharova K; Department of Biology, Lund University, 22362, Lund, Sweden.; Innovation Centre - STB, 83110, Tczew, Poland.; Anara, 23132, Trelleborg, Sweden.; Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05110, Jabłonna, Poland., Gregory PC; Anara, 23132, Trelleborg, Sweden.; Abbott Laboratories GmbH, 30173, Hannover, Germany., Weström B; Department of Biology, Lund University, 22362, Lund, Sweden., Podpryatov SE; Anara, 23132, Trelleborg, Sweden.; Clinical Research Centre of Bonding/Welding Surgery and New Surgical Technologies at Kyiv Municipal Hospital Clinic No. 1, 02091, Kyiv, Ukraine., Podpriatov SS; Anara, 23132, Trelleborg, Sweden.; Clinical Research Centre of Bonding/Welding Surgery and New Surgical Technologies at Kyiv Municipal Hospital Clinic No. 1, 02091, Kyiv, Ukraine., Woliński J; Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05110, Jabłonna, Poland., Repich H; Department of Biology, Lund University, 22362, Lund, Sweden.; Innovation Centre - STB, 83110, Tczew, Poland.; Anara, 23132, Trelleborg, Sweden., Wierup N; Department of Clinical Sciences, Lund University Diabetes Centre, 22100, Malmö, Sweden., Lozinska L; Department of Biology, Lund University, 22362, Lund, Sweden. liudmyla.lozinska@biol.lu.se.; Anara, 23132, Trelleborg, Sweden. liudmyla.lozinska@biol.lu.se.; Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, 76018, Ivano-Frankivsk, Ukraine. liudmyla.lozinska@biol.lu.se.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Aug 17; Vol. 7 (1), pp. 8628. Date of Electronic Publication: 2017 Aug 17.
DOI: 10.1038/s41598-017-07387-2
Abstrakt: The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes - probably amylase or its peptides - on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.
Databáze: MEDLINE
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