Developmental Screening in Pediatric Sickle Cell Disease: Disease-Related Risk and Screening Outcomes in 4 Year Olds.
| Autor: | Schatz J; Department of Psychology, University of South Carolina, Columbia, SC; †Department of Pediatrics, Medical University of South Carolina, Charleston, SC; ‡Department of Pediatrics, University of South Carolina, Columbia, SC., Schlenz A, Reinman L, Smith K, Roberts CW |
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| Jazyk: | angličtina |
| Zdroj: | Journal of developmental and behavioral pediatrics : JDBP [J Dev Behav Pediatr] 2017 Oct; Vol. 38 (8), pp. 654-662. |
| DOI: | 10.1097/DBP.0000000000000486 |
| Abstrakt: | Objective: Studies of early child development in sickle cell disease (SCD) have found modest associations between disease-related risks and developmental status in infants and toddlers, but such associations are evident by early elementary school. We screened 4-year-old children with SCD using 2 screening strategies to assess if biomedical risk factors for neurologic disease are related to developmental screening outcomes at this intermediate age. Methods: Seventy-seven 4-year-old children with SCD (M = 4.5 yrs, SD = 0.3 yrs) completed developmental screenings at routine hematology visits using child testing (Fluharty Preschool Speech and Language Screenings Test, 2nd edition) and parent-report (Ages and Stages Questionnaire, 2nd edition) procedures. Genotype and other biomedical variables were coded from medical records. Results: Children with higher-risk SCD genotypes (n = 52) showed lower performance than children with lower-risk genotypes (n = 25) on a measure related to neurologic disease risk in older children (syntactic processing); genotype risk was also related to rates of positive screenings on parent-reported developmental milestones (52% positive screenings in high-risk genotypes vs 12% in low-risk genotypes). Screening outcomes were also related to transcranial Doppler ultrasound findings assessing cerebral blood flow. Conclusion: Developmental screening at age 4 may be a useful target age for identifying preschoolers with sickle cell-related neurodevelopmental concerns. Parent report of developmental milestones and behavioral testing each may have a role in screening for children in need of follow-up services to address potential neurodevelopmental effects from SCD. |
| Databáze: | MEDLINE |
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