Homer1a protein expression in schizophrenia, bipolar disorder, and major depression.

Autor: Leber SL; Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria.; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA., Llenos IC; Laboratory of Brain Research and Neuropathology, The Stanley Medical Research Institute, Bethesda, USA.; Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Department of Pathology, Paracelsus Medical University, Salzburg, Austria., Miller CL; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA., Dulay JR; Laboratory of Brain Research and Neuropathology, The Stanley Medical Research Institute, Bethesda, USA.; Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Haybaeck J; Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria.; Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Weis S; Laboratory of Brain Research and Neuropathology, The Stanley Medical Research Institute, Bethesda, USA. serge.weis@kepleruniklinikum.at.; Division of Neuropathology, Department of Pathology and Neuropathology, Neuromed Campus, Kepler University Hospital, School of Medicine, Johannes Kepler University, Wagner-Jauregg-Weg 15, 4020, Linz, Austria. serge.weis@kepleruniklinikum.at.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2017 Oct; Vol. 124 (10), pp. 1261-1273. Date of Electronic Publication: 2017 Aug 16.
DOI: 10.1007/s00702-017-1776-x
Abstrakt: In recent years, there was growing interest in postsynaptic density proteins in the central nervous system. Of the most important candidates of this specialized region are proteins belonging to the Homer protein family. This family of scaffolding proteins is suspected to participate in the pathogenesis of a variety of diseases. The present study aims to compare Homer1a expression in the hippocampus and cingulate gyrus of patients with major psychiatric disorders including schizophrenia, bipolar disorder and major depression. Immunohistochemistry was used to analyze changes of Homer1a protein expression in the hippocampal formation and the cingulate gyrus from the respective disease groups. Glial cells of the cingulate gyrus gray matter showed decreased Homer1a levels in bipolar disorder when compared to controls. The same results were seen when comparing cingulate gyrus gray matter glial cells in bipolar disorder with major depression. Stratum oriens glial cells of the hippocampus showed decreased Homer1a levels in bipolar disorder when compared to controls and major depression. Stratum lacunosum glial cells showed decreased Homer1a levels in bipolar disorder when compared to major depression. In stratum oriens interneurons Homer1a levels were increased in all disease groups when compared to controls. Stratum lucidum axons showed decreased Homer1a levels in bipolar disorder when compared to controls. Our data demonstrate altered Homer1a levels in specific brain regions and cell types of patients suffering from schizophrenia, bipolar disorder and major depression. These findings support the role of Homer proteins as interesting candidates in neuropsychiatric pathophysiology and treatment.
Databáze: MEDLINE
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