HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study.

Autor: Fagbemi KA; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Medehouenou TCM; Laboratoire de Recherche en Biologie Appliquée, Ecole Polytechnique d'Abomey-Calavi, Université d'Abomey-Calavi, Abomey-Calavi, Benin., Azonbakin S; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Adjagba M; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Osseni R; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Ahoueya J; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Agbanlinsou A; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Darboux R; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin., Baba-Moussa L; Laboratoire de Biologie et de Typage Moléculaire en Microbiologie, Université d'Abomey-Calavi, Abomey-Calavi, Benin., Laleye A; UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin.
Jazyk: angličtina
Zdroj: Journal of diabetes research [J Diabetes Res] 2017; Vol. 2017, pp. 6053764. Date of Electronic Publication: 2017 Jul 20.
DOI: 10.1155/2017/6053764
Abstrakt: Background: Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D.
Material and Methods: Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes.
Results: Participants were aged 1-24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02.
Conclusion: Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.
Databáze: MEDLINE
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