Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.

Autor: Leo PJ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia., Madeleine MM; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America., Wang S; Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, United States of America., Schwartz SM; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America., Newell F; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia., Pettersson-Kymmer U; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Hemminki K; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Primary Health Care Research, Lund University, Lund, Sweden., Hallmans G; Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Tiews S; MHC Laboratory for Cytopathology, Dr.Steinberg GmbH, Soest, Germany., Steinberg W; MHC Laboratory for Cytopathology, Dr.Steinberg GmbH, Soest, Germany., Rader JS; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America., Castro F; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Safaeian M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America., Franco EL; Division of Cancer Epidemiology, McGill University, Montreal, QC, Canada., Coutlée F; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada., Ohlsson C; Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden.; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cortes A; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia., Marshall M; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia., Mukhopadhyay P; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia., Cremin K; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia., Johnson LG; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America., Trimble CL; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Garland S; Regional World Health Organisation Human Papillomavirus Laboratory Network, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, 3052, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria, 3052, Australia., Tabrizi SN; Department of Obstetrics and Gynaecology, University of Melbourne, Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria, 3052, Australia., Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America., Sitas F; Cancer Council NSW, Sydney, NSW, Australia.; Sydney School of Public Health, University of Sydney, Camperdown, NSW, Australia.; School of Public Health and Community Medicine, University of New South Wales, Kensington, NSW, Australia., Little J; School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada., Cruickshank M; Division of Medical Education, University of Aberdeen, Aberdeen, Scotland., Frazer IH; Faculty of Medicine and Biomedical Sciences, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia., Hildesheim A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America., Brown MA; Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia.
Jazyk: angličtina
Zdroj: PLoS genetics [PLoS Genet] 2017 Aug 14; Vol. 13 (8), pp. e1006866. Date of Electronic Publication: 2017 Aug 14 (Print Publication: 2017).
DOI: 10.1371/journal.pgen.1006866
Abstrakt: A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B. Furthermore, 36% (standard error 2.4%) of liability of HPV-associated cervical pre-cancer and cancer is determined by common genetic variants. Women in the highest 10% of genetic risk scores have approximately >7.1% risk, and those in the highest 5% have approximately >21.6% risk, of developing cervical neoplasia. Future studies should examine genetic risk prediction in assessing the risk of cervical neoplasia further, in combination with other screening methods.
Databáze: MEDLINE