Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films.

Autor: Mahon CS; Chemical Nanoscience Laboratory, School of Chemistry, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., McGurk CJ; Chemical Nanoscience Laboratory, School of Chemistry, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK., Watson SMD; Chemical Nanoscience Laboratory, School of Chemistry, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK., Fascione MA; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Sakonsinsiri C; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Department of Biochemistry, Faculty of Medicine, Khon Kean University, Muang District, Khon Kaen, 40002, Thailand., Turnbull WB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Fulton DA; Chemical Nanoscience Laboratory, School of Chemistry, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Oct 09; Vol. 56 (42), pp. 12913-12918. Date of Electronic Publication: 2017 Sep 08.
DOI: 10.1002/anie.201706379
Abstrakt: We describe single-chain polymer nanoparticles (SCNPs) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through a molecular recognition-mediated crosslinking process. The SCNPs utilise molecular recognition with surface-immobilised proteins to concentrate upon a substrate, bringing the SCNPs into close spatial proximity with one another and allowing their dynamic covalent crosslinkers to undergo intra- to interpolymer chain crosslinking leading to the formation of polymeric film. SCNPs must possess both the capacity for specific molecular recognition and a dynamic nature to their intramolecular crosslinkers to form polymer films, and an investigation of the initial phase of film formation indicates it proceeds from features which form upon the surface then grow predominantly in the xy directions. This approach to polymer film formation presents a potential method to "wrap" surfaces displaying molecular recognition motifs-which could potentially include viral, cellular and bacterial surfaces or artificial surfaces displaying multivalent recognition motifs-within a layer of polymer film.
(© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Databáze: MEDLINE
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