Unresectable squamous cell carcinoma of upper trachea with long-term survival after concurrent chemoradiotherapy.

Autor:	Yathiraj PH; Department of Radiotherapy and Oncology, Manipal University, Kasturba Medical College, Manipal, Karnataka, India., Ail S; Department of Radiotherapy and Oncology, Manipal University, Kasturba Medical College, Manipal, Karnataka, India., Singh A; Department of Radiotherapy and Oncology, Manipal University, Kasturba Medical College, Manipal, Karnataka, India., Mamidipudi V; Department of Radiotherapy and Oncology, Manipal University, Kasturba Medical College, Manipal, Karnataka, India.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2017 Aug 11; Vol. 2017. Date of Electronic Publication: 2017 Aug 11.
DOI:	10.1136/bcr-2017-221284
Abstrakt:	Upper tracheal malignancies are rare, and long-term survival is even rarer, especially among the unresectable malignancies. A 66-year-old chronic smoker was diagnosed as a locally advanced, non-metastatic squamous cell carcinoma of the upper trachea. Being unresectable, he was treated with six cycles of concurrent weekly cisplatin and three-dimensional conformal radiotherapy to a dose of 60 Gy in 30 fractions over 6 weeks. Follow-up imaging at 6 and 12 months revealed no disease. Our patient is presently 36 months post-treatment and is disease free without tracheal necrosis, fistula or radiation pneumonitis but developed hypothyroidism and is presently euthyroid. Concurrent chemoradiotherapy appears safe up to 3 years at least without any necrosis and is effective in controlling local disease. Meticulous planning obviates the need for higher technology like motion management techniques or intensity-modulated radiotherapy. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
Databáze:	MEDLINE
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