Photochemical Acceleration of DNA Strand Displacement by Using Ultrafast DNA Photo-crosslinking.

Autor: Nakamura S; School of Materials Science, Japan Advanced Institute Science and Technology, 1-1, Asahidai, Nomi, Ishikawa, 923-1292, Japan., Hashimoto H; School of Materials Science, Japan Advanced Institute Science and Technology, 1-1, Asahidai, Nomi, Ishikawa, 923-1292, Japan., Kobayashi S; Department of Computer Science, University of Electro-Communications, 1-1-1, Chofugaoka, Chofu, Tokyo, 182-8585, Japan., Fujimoto K; School of Materials Science, Japan Advanced Institute Science and Technology, 1-1, Asahidai, Nomi, Ishikawa, 923-1292, Japan.
Jazyk: angličtina
Zdroj: Chembiochem : a European journal of chemical biology [Chembiochem] 2017 Oct 18; Vol. 18 (20), pp. 1984-1989. Date of Electronic Publication: 2017 Aug 29.
DOI: 10.1002/cbic.201700430
Abstrakt: DNA strand displacement is an essential reaction in genetic recombination, biological processes, and DNA nanotechnology. In particular, various DNA nanodevices enable complicated calculations. However, it takes time before the output is obtained, so acceleration of DNA strand displacement is required for a rapid-response DNA nanodevice. Herein, DNA strand displacement by using DNA photo-crosslinking to accelerate this displacement is evaluated. The DNA photo-crosslinking of 3-cyanovinylcarbazole ( CNV K) was accelerated at least 20 times, showing a faster DNA strand displacement. The rate of photo-crosslinking is a key factor and the rate of DNA strand displacement is accelerated through ultrafast photo-crosslinking. The rate of DNA strand displacement was regulated by photoirradiation energy.
(© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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